Koeman J

No ORCID on file · 2 papers in corpus · active 2019-2022
2022
SWI/SNF Antagonism of PRC2 Mediates Estrogen-Induced Progesterone Receptor Expression.
Cells ·doi:10.3390/cells11061000

Endometrial cancer (EC) is characterized by high estrogen levels unopposed by progesterone. Treatment with progestins is standard for early EC, but the response to progestins is dependent on progesterone receptor (PGR) expression. Here, we …

2019
ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion.
Nature communications ·doi:10.1038/s41467-019-11403-6

ARID1A and PI3-Kinase (PI3K) pathway alterations are common in neoplasms originating from the uterine endometrium. Here we show that monoallelic loss of ARID1A in the mouse endometrial epithelium is sufficient for vaginal bleeding when comb…