Xu J

BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been shown to disrupt normal follicular development and ovulation. However, it is unknown which specific PFAS in follicular fluid negatively impact oocyte development and…

BACKGROUND: Adenomyosis is thought to be associated with adverse perinatal outcomes. This study aimed to assess the relationship between pre-pregnancy uterine volume and preterm birth in singleton gravid women with adenomyosis. METHODS: We…

Abstract Background Adenomyosis is a chronic gynecological condition characterized by the presence of endometrial glands and stroma within the myometrium, resulting in dysmenorrhea, menorrhagia, and infertility. Objectives This study was…

We present an extremely rare heterotopic pregnancy (HP) in a 33-year-old patient with multiple adenomyosis surgeries and bilateral salpingectomy, who conceived via assisted reproductive technology (ART). According to a review of the literat…

BACKGROUND: Chronic enteropathy associated with solute carrier organic anion transporter family member 2A1 (SLCO2A1) (CEAS) is a rare autosomal recessive hereditary disease characterized by anemia, hypoproteinemia, abdominal pain, diarrhea,…

OBJECTIVE: This study aims to develop and validate an artificial intelligence (AI) model based on ultrasound (US) videos and images to improve the performance of junior sonologists in detecting deep infiltrating endometriosis (DE). METHODS…

CAPSULE: The gestational age at fetal reduction had no effect on pregnancy outcome when reduction was performed before 17 + 4 weeks. After 17 + 4 weeks, the later the fetal reduction was done, the earlier the delivery and lower the birthwei…

DNA methylation is a common endogenous chemical modification in eukaryotic DNA, primarily involving the covalent attachment of a methyl group to the fifth carbon of cytosine residues, leading to the formation of 5-methylcytosine (5mC). This…

INTRODUCTION: The mechanisms of estrogen in glucose metabolism are well established; however, the role of this hormone in glucose absorption remains unclear. In this study, we investigated the effects of estrogen on glucose absorption in hu…

The reprogrammed osteogenic phenotype of vascular smooth muscle cells (VSMCs) is considered a critical mechanism of vascular calcification (VC) in chronic kidney disease (CKD). Currently, the RNA N6-methyladenosine (m6A) modification is dec…

BACKGROUND: The aim of this study was to investigate the role of miR-361-5p (a tumor suppressor) in regulating granulosa cell function by targeting SLC25A24, a key mitochondrial protein, to uncover potential therapeutic targets for diminish…

The incidence and mortality rates of liver cancer in China remain elevated. Although early-stage liver cancer is amenable to surgical resection, a significant proportion of patients are diagnosed at advanced stages. Currently, in addition t…

OBJECTIVES: This study aimed to investigate the distribution of molecular signatures in endometriosis- associated ovarian cancer (EAOC) and to develop a prognostic model based on these molecular signatures. METHODS: We retrospectively analy…

Acute pancreatitis (AP) is a severe inflammatory disorder of the pancreas, characterized by high morbidity and mortality rates. Despite significant advancements in understanding the pathophysiological mechanisms of AP, current treatment opt…

OBJECTIVES: To carry out a quantitative assessment of the therapeutic effect of Chinese herbal medicine (CHM), with Rehmannia glutinosa as the main ingredient, in treating perimenopausal syndrome (PMS) in breast cancer patients. METHODS: R…

Abstract Adenomyosis is a prevalent and non-cancerous uterine disease which can significantly impaired the fertility of reproductive-age women. However, the etiology, as well as the cellular and molecular mechanism underlying adenomyosis re…

INTRODUCTION: Adenomyosis is a prevalent gynaecological disorder affecting women of reproductive age, yet the underlying etiology and cellular-molecular mechanisms driving its pathogenesis remain poorly understood. Gonadotropin-releasing ho…

Prostaglandin E2 (PGE2) signaling through EP2 and EP4 receptors is crucial in regulating inflammation, pain, and cancer progression. While selective and dual antagonists for these receptors hold therapeutic potential, their binding mechanis…

Performing robotic hysterectomy (RH) on large uteri is a significant challenge. This study aims to investigate the impact of various risk factors on surgical outcomes and to identify the most effective surgical approach for performing RH on…

While infections have been implicated in endometriosis pathogenesis, the role of human papillomavirus (HPV) remains unclear. This study combined a meta-analysis of seven studies with a case-control study ( n = 432 surgically treated patient…

m6A regulators were demonstrated to modulate the functions of intestinal epithelial and immune cells in the ulcerative colitis. This study aimed to elucidate whether and how the m6A reader heterogeneous nuclear ribonucleoprotein C (HNRNPC) …

Spalt-like transcription factor 4 (SALL4) plays a vital role in the progression of many human diseases. However, the role and mechanism of SALL4 regulates in keloid formation remain unclear. The mRNA levels of SALL4 and ubiquitin-specific p…

RATIONALE: MER proto-oncogene tyrosine kinase (MerTK) is a key receptor for the clearance of apoptotic cells (efferocytosis) and plays important roles in redox-related human diseases. We will explore MerTK biology in human cells, tissues, a…

PURPOSE: To explore the early diagnostic value of superb microvascular imaging (SMI) features within the rotator cuff gap for frozen shoulder. PATIENTS AND METHODS: This prospective study enrolled patients with acute early-stage frozen sho…

BACKGROUND: Non-invasive chromosome screening (NICS) and trophectoderm biopsy preimplantation genetic testing for aneuploidy (TE-PGT) were both applied for embryo ploidy detection, However, the cumulative live birth rates (CLBR) of NICS and…