Zhang Y

Bacterial extracellular vesicles (BEVs), nanoscale membrane-bound particles secreted by bacteria, have emerged as pivotal mediators of host-microbe communication, particularly in the context of inflammatory diseases. By delivering diverse b…

Interstitial cystitis (IC), also known as bladder pain syndrome (BPS), is a chronic and devastating urologic disease. Its characteristics include the damage to the barrier function of bladder mucosa, inflammation related to nerve activity a…

BACKGROUND: Patients undergoing assisted reproductive technology (ART) frequently manifest sleep disturbances and psychological morbidity. This study examined associations between cerebral activation patterns, sleep quality, and psychologic…

STUDY QUESTION: What is the current landscape of randomized controlled trials (RCTs) evaluating stem cell-based therapies for women's reproductive diseases, and how effectively has preclinical research informed their clinical translation? …

Accurate pre-operative discrimination between ovarian endometriomas (EMs) and other benign ovarian tumors is crucial for surgical planning and fertility counseling. This study aimed to evaluate the diagnostic performance of serum CA125, CA1…

BACKGROUND: Endometriosis (EMs) is a common gynecological disorder associated with infertility. EMs patients often require assisted reproductive technology (ART) but exhibit lower success rates. This study aimed to characterize the follicul…

Endometriosis, affecting approximately 10% of reproductive-aged women worldwide, is widely recognized as a chronic inflammatory disease. Inflammation-related genes (IRGs) play a crucial role in the occurrence and progression of various dise…

OBJECTIVE: To evaluate the long-term efficacy of Chinese herbal medicine (CHM) in enhancing reproductive outcomes and reducing recurrence rates among endometriosis-associated infertility women infertile women. METHODS: This study is a retr…

Currently available classification criteria for obstetric antiphospholipid syndrome (OAPS) are often overly strict and may miss a considerable number of patients with so-called "non-criteria-defined OAPS". We aimed to establish a diagnostic…

Abstract Objective This study aims to systematically compare the short-term efficacy and safety differences between daily oral 2 mg Dienogest (DNG) and daily oral 10 mg Mifepristone (MIF) in the treatment of patients with symptomatic aden…

BACKGROUND: Endometriosis-associated ovarian cancer is a distinct form of epithelial ovarian cancer that arises from the malignant transformation of benign endometriotic lesions. While epithelial-mesenchymal transition is acknowledged as a …

BackgroundAdnexal masses discovered after hysterectomy are common, but the proportion that is malignant is low, and existing risk-stratification systems such as O-RADS were not developed or validated in this population. We aimed to develop …

Early detection of asymptomatic ovarian cancer (asym-OC) remains a critical challenge, the failure of which underlies its high mortality. Performing serum peptidomic profiling of 843 participants in the cohort SOCFCP, we distill 1,081 initi…

INTRODUCTION: Imaging is increasingly used for adult endometriosis, but evidence supporting adolescent imaging approaches remains unclear. This scoping review mapped evidence on imaging-based diagnosis of endometriosis in adolescents and yo…

BACKGROUND: In recent years, microRNAs have attracted increasing attention for their potential diagnostic and prognostic value across various diseases. This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of mi…

Yuru Wang,1,* Zihan Zhu,2,* Xu Jin,3 Zhaoyan Ding,2 Wen Zhong,2 Yueming Zhang,1 Songwei Feng,1,4 Ting Wu1 1Department of Obstetrics and Gynaecology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Rep…

BACKGROUND: Endometriosis is a chronic, estrogen-dependent inflammatory disorder that causes substantial pain and infertility. Observational studies have reported higher rates of multiple psychiatric disorders among individuals with endomet…

BACKGROUND: The follicular-phase long GnRHa protocol is a common protocol in COH. This study mainly analyzed the recovery of FSH levels on the day of Gn initiation compared with basal FSH levels on the day of downregulation and studied the …

ObjectivesThe relationship between clomiphene citrate (CC) dosing regimens and adverse reproductive outcomes has not been fully elucidated, both with and without use of in vitro fertilisation (IVF). We aimed to study the association between…

BACKGROUND: Assisted reproductive technologies (ART) have been proven to be associated with the increased risk of pregnancy complications such as gestational hypertension and neonatal disorders, which may have negative effects on offspring'…

BACKGROUND: First implantation failure (FIF) remains a significant challenge in in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET), and a considerable proportion of affected women subsequently progress to …

PURPOSE: Regarding anesthesia management for high-intensity focused ultrasound (HIFU) treatment of uterine adenomyosis, existing research is limited. While considered non-invasive, HIFU ablation carries risks such as thermal injury to adjac…

Endometriosis (Ems) is a benign disease characterized by invasion and migration. Abnormally expressed mRNAs regulate its progression. In this study, we analyzed GEO datasets and identified significant upregulation of PDLIM3 in ectopic endom…