Sha Wang
ORCID: 0000-0001-6231-1718
· 40 papers in corpus
other
2020
RESEARCH QUESTION: Is abnormal gene module expression in the eutopic endometrium related to the occurrence of endometriosis? DESIGN: Nine datasets of normal and eutopic endometrium were searched and collected through the National Center fo…
lab-animal
2020
The inner myometrium, also called the junctional zone (JZ), is believed to play a major role in the development of adenomyosis. Recently, we found that the lethal-7a (Let-7a) microRNA (miRNA) was clearly downregulated in the miRNA expressio…
lab-animal
2020
We investigated the role of oestrogen receptor 1 (ESR1) in regulating the [Ca2+]i concentration in the junctional zone (JZ) and its effect on adenomyosis. JZ smooth muscle cells (JZSMCs) were isolated from 17 control and 24 adenomyotic uter…
observational
2019
OBJECTIVE: To establish and validate a decision tree model to predict the recurrence of intrauterine adhesions (IUAs) in patients after separation of moderate-to-severe IUAs. DESIGN: A retrospective study. SETTING: A tertiary hysteroscopi…
other
2019
OBJECTIVE: Adenomyosis is a common gynecologic benign disease that may have a life-long negative impact on women. Previous studies have indicated that the endocannabinoid system may participate in the progress of endometriosis. Our research…
other
2019
The myometrium, especially the junctional zone (JZ), is now well documented to have a role in the pathogenesis of adenomyosis. Cannabinoid receptors have been shown to participate in the establishment of endometriosis and its pain perceptio…
lab-animal
2018
Epithelial‑mesenchymal transition (EMT) has been associated with the pathogenesis of adenomyosis; focal adhesion kinase (FAK) serves an important role in the EMT process. The aim of the present study was to determine whether FAK regulates E…
review
2018
The management of adenomyosis remains a great challenge to practicing gynaecologists. Until recently, hysterectomy has been the only definitive treatment in women who have completed child bearing. A number of nonsurgical and minimally invas…
other
2017
OBJECTIVE: To compare the expression of G-protein-coupled estrogen receptor (GPER) in the junctional zone and outer myometrium of the proliferative and secretory phases of women with and without adenomyosis. METHODS: A total of 76 women we…
lab-animal
2015
Adenomyosis (ADS) is a common estrogen-dependent gynecological disease with unknown etiology. Recent models favor abnormal thickening of the junctional zone (JZ) may be the causative factor in the development of ADS. RhoA, a small guanosine…
lab-animal
2015
OBJECTIVE: To investigate the regulation mechanism of estrogen on the free calcium of smooth muscle cells at the endometrial-myometrial interface (EMI) in uteri with adenomyosis. METHODS: From September 2011 to November 2012, 59 uterine my…
observational
2014
OBJECTIVE: To explore the ultrastructural features of endometrial-myometrial interface (EMI) of adenomyosis and normal myometrium. METHODS: From May 2010 to September 2013, 102 uterine myometrial specimens were obtained from 102 patients u…
other
2013
OBJECTIVE: To investigate the relationship between nitric oxide and contractile disfunction of junctional zone of smooth muscle by detecting the expression of nitric oxide in uterine junctional zone in patients with adenomyosis. METHODS: F…
other
2013
OBJECTIVE: To investigate the expression of RhoA and Rho kinase in junctional zone (JZ) of adenomyosis and normal myometrium and explore its relationship with severity of dysmenorrheal. METHODS: From Mar. to Dec. 2012, 32 cases with adenom…
lab-animal
2012
OBJECTIVE: To investigate the effect and mechanism of estrodial (E(2)) on intracellular free calcium in the endometrial-myometrial interface (EMI) smooth muscle cells from uteri with adenomyosis. METHODS: From March 2011 to October 2011, 1…