Michael C. Velarde

ORCID: 0000-0003-2384-5404 · 8 papers in corpus · active 2009-2023

Study types

  • article 6
  • review 2

Condition tags

  • endometriosis 8
  • infertility 3
  • dysmenorrhea 1
review 2023
Endometriosis as a highly relevant yet neglected gynecologic condition in Asian women
Endocrine connections ·doi:10.1530/ec-23-0169

Endometriosis is a chronic, debilitating disease characterized by the growth of endometrial tissues outside the endometrium. Its prevalence seems to differ across ethnicities, with the disease affecting and presenting with advanced stages i…

article 2023
Non-surgical Syngeneic Model of Endometriosis in Ovary-intact Outbred Mice
·doi:10.56899/152.03.24

Intraperitoneal injection of endometrial tissues into inbred mice such as C57BL/6J is widely used as a model to study endometriosis, a disease characterized by the abnormal proliferation of endometrial cells which invade various tissues wit…

article 2018
Diet and endometriosis-revisiting the linkages to inflammation
·doi:10.1177/2284026518769022

Endometriosis is a chronic inflammatory condition that may cause pelvic pain, dysmenorrhea, and/or infertility in women of reproductive age. While treatments may include medical or surgical management, the majority of therapeutic options ar…

article 2015
Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis1
Biology of reproduction ·doi:10.1095/biolreprod.115.130260

Krüppel-like Factor (KLF) 13 and the closely related KLF9 are members of the Sp/KLF family of transcription factors that have collectively emerged as essential regulators of tissue development, differentiation, proliferation, and programmed…

article 2012
Krüppel-Like Factor 9 and Progesterone Receptor Coregulation of Decidualizing Endometrial Stromal Cells: Implications for the Pathogenesis of Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2011-2562

CONTEXT: Endometriosis is characterized by progesterone resistance and associated with infertility. Krüppel-like factor 9 (KLF9) is a progesterone receptor (PGR)-interacting protein, and mice null for Klf9 are subfertile. Whether loss of KL…

review 2010
Altered Gene Expression Profiling in Endometrium: Evidence for Progesterone Resistance
Seminars in reproductive medicine ·doi:10.1055/s-0029-1242994

Progesterone plays an important role in regulating multiple events in the uterus. It controls endometrial proliferation and differentiation, which are important for uterine function. Dysregulation of progesterone signaling leads to impaired…

article 2009
Increased Mitogen-Activated Protein Kinase Kinase/Extracellularly Regulated Kinase Activity in Human Endometrial Stromal Fibroblasts of Women with Endometriosis Reduces 3′,5′-Cyclic Adenosine 5′-Monophosphate Inhibition of Cyclin D1
Endocrinology ·doi:10.1210/en.2009-0389

Endometriosis is characterized by endometrial tissue growth outside the uterus, due primarily to survival, proliferation, and neoangiogenesis of eutopic endometrial cells and fragments refluxed into the peritoneal cavity during menses. Alth…

article 2009
The Progesterone Receptor Coactivator Hic-5 Is Involved in the Pathophysiology of Endometriosis
Endocrinology ·doi:10.1210/en.2009-0008

Endometriosis is an estrogen-dependent disorder primarily associated with pelvic pain and infertility in up to 10% of women of reproductive age. Recent studies suggest that resistance to progesterone action may contribute to the development…