Daniel I Chasman

No ORCID on file · 9 papers in corpus · active 2017-2023

Study types

  • review 3
  • meta-analysis 2
  • other 2
  • article 1

Condition tags

  • endometriosis 8
  • mesh:D004715 7
  • infertility 1
other 2023
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
Nature human behaviour ·doi:10.1038/s41562-023-01528-6

Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identified 43 genomic loci a…

meta-analysis 2023
The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
Nature genetics ·doi:10.1038/s41588-023-01323-z

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genom…

2022
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease
·doi:10.21203/rs.3.rs-1463822/v1
review 2021
Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways
Human Reproduction ·doi:10.1093/humrep/deab254

STUDY QUESTION: Is there a shared genetic or causal association of endometriosis with asthma or what biological mechanisms may underlie their potential relationships? SUMMARY ANSWER: Our results confirm a significant but non-causal associat…

article 2020
Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality
Human genetics ·doi:10.1007/s00439-020-02223-6
review 2020
Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity
Genes ·doi:10.3390/genes11030268

Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected by chance. However, the aetiology and biological mechanisms underlying their comorbidity remain unknown. Here we e…

review 2019
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis
Nature communications ·doi:10.1038/s41467-019-12536-4

Abstract Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 …

other 2017
Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry
Scientific reports ·doi:10.1038/s41598-017-10440-9

Genome-wide association (GWA) studies have identified 19 independent common risk loci for endometriosis. Most of the GWA variants are non-coding and the genes responsible for the association signals have not been identified. Herein, we aime…

meta-analysis 2017
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism
Nature communications ·doi:10.1038/ncomms15539

Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide ass…