Sheldon IM

No ORCID on file · 4 papers in corpus · active 2011-2023
2023
Induced endometrial inflammation compromises conceptus development in dairy cattle†.
Biology of reproduction ·doi:10.1093/biolre/ioad088

Endometrial inflammation is associated with reduced pregnancy per artificial insemination (AI) and increased pregnancy loss in cows. It was hypothesized that induced endometritis alters histotroph composition and induces inflammatory signat…

2022
Lipopolysaccharide alters CEBPβ signaling and reduces estradiol production in bovine granulosa cells.
CABI agriculture and bioscience ·doi:10.1186/s43170-022-00133-3

BackgroundBacterial infection of the uterus in postpartum dairy cows limits ovarian follicle growth, reduces blood estradiol concentrations, and leads to accumulation of bacterial lipopolysaccharide (LPS) in ovarian follicular fluid. Althou…

2022
The endometrial transcriptomic response to pregnancy is altered in cows after uterine infection.
PloS one ·doi:10.1371/journal.pone.0265062

Pregnancy induces changes in the transcriptome of the bovine endometrium from 15 days after insemination. However, pregnancy is less likely to occur if cows had a postpartum bacterial infection of the uterus, even after the resolution of di…

2011
Lipopolysaccharide initiates inflammation in bovine granulosa cells via the TLR4 pathway and perturbs oocyte meiotic progression in vitro.
Endocrinology ·doi:10.1210/en.2011-1124

Infections of the reproductive tract or mammary gland with Gram-negative bacteria perturb ovarian function, follicular growth, and fecundity in cattle. We hypothesized that lipopolysaccharide (LPS) from Gram-negative bacteria stimulates an …