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OPINION article Front. Reprod. Health, 11 January 2022Sec. Gynecology Volume 3 - 2021 | https://doi.org/10.3389/frph.2021.809366
Olfactomedin-4 (OLFM-4) is an extracellular matrix protein that is highly expressed in human endometrium. We have examined the regulation and function of OLFM-4 in normal endometrium and in cases of endometriosis and endometrial cancer. OLF…
Context: substantial evidence suggests that the expression of steroid metabolizing enzymes in endometriosis is altered, turning the ectopic endometrium into a source of 17β-estradiol. However, whether these differences result in a net incre…
CONTEXT: substantial evidence suggests that the expression of steroid metabolizing enzymes in endometriosis is altered, turning the ectopic endometrium into a source of 17beta-estradiol. However, whether these differences result in a net in…
Tissue integrity of the regurgitated endometrium is pivotal to the development of endometriosis. Occult, submicroscopic lesions occur. Diagnostic laparoscopy may underestimate as well as overestimate the presence of endometriosis.
Lone Hummelshoj1†, Andrew Prentice2 & Patrick Groothuis3 †Author for correspondence 1Endometriosis.ORG, 89 Southgate Road, London, N1 3JS, UK. Tel.: +44 (0)7710 065 164; Fax: +44 (0)20 7354 4708; E-mail: [email protected] 2University D…