Kirkland JL

No ORCID on file · 4 papers in corpus · active 2016-2020
2020
Aging ·doi:10.18632/aging.102772

The uterine fibrosis contributes to gestational outcomes. Collagen deposition in the uterus is related to uterine aging. Senolytic therapies are an option for reducing health complications related to aging. We investigated effects of aging …

2018
Physiology (Bethesda, Md.) ·doi:10.1152/physiol.00024.2018

Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cel…

2017
The journals of gerontology. Series A, Biological sciences and medical sciences ·doi:10.1093/gerona/glx026

BackgroundThe cause-effect relationship between bilateral oophorectomy and accelerated aging remains controversial. We conducted new analyses to further address this controversy.MethodsThe Rochester Epidemiology Project records-linkage syst…

2016
Mayo Clinic proceedings ·doi:10.1016/j.mayocp.2016.08.002

ObjectiveTo study the association between bilateral oophorectomy and the rate of accumulation of multimorbidity.Patients and methodsIn this historical cohort study, the Rochester Epidemiology Project records-linkage system was used to ident…