Cheng Zhang

BACKGROUND: Benign gallbladder disease, including gallstones, gallbladder polyps, and gallbladder adenomyosis, is one of the most common disorders of the digestive system worldwide and poses a substantial clinical and economic burden. Despi…

Accurate interpretation of genomic variants remains a major bottleneck in precision oncology, due in part to fragmented knowledge across databases and limited integration between clinical evidence and population-scale genomic datasets. Here…

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic condition in reproductive-aged women, linked to infertility and long-term cardiometabolic risk. Early identification remains challenging because current diagnosis …

Large-scale deep endometrial injury has a serious impact on the reproductive health of women, necessitating the development of novel therapeutic approaches. Treatment strategies using single factor may not perfectly match the intricate and …

Abstract Objective To analyze the clinical characteristics of hospitalized patients with benign gallbladder diseases based on a large dataset, and compare these findings with those from the physical examination population in existing liter…

Melatonin, as an endocrine neurotransmitter, can promote the development of the ovary. Meanwhile, it also has protective effect on the ovary as an antioxidant. Thyroid hormone (TH) is essential for normal human reproductive function. Many s…

All types of ginger have common fundamental components, although they possess distinct strengths and inclinations when it comes to effectiveness and medicinal applications. Fresh ginger possesses the ability to effectively stimulate movemen…

Benzyl butyl phthalate (BBP) is a chemical softener and plasticizer commonly used in toys, food packaging, wallpaper, detergents and shampoos. The estrogenic actions of BBP have detrimental effects on humans and animals. In this study, the …

BACKGROUND: Pancreaticobiliary reflux (PBR) causes chronic inflammation of the gallbladder mucosa and changes in the bile components, which are known to promote gallstone formation. This study aimed to investigate the bile biochemistry chan…

The T cell immunoglobulin mucin molecule 3 (TIM-3), as a negative regulatory immune checkpoint, plays an important role in cellular immunity by binding to its ligand galectin-9 (Gal-9). Under abnormal conditions, this pathway can regulate t…

BACKGROUND: Ovarian squamous cell carcinoma (SCC) is a rare cancer with possible poor survival, however no direct evidence supports this viewpoint and the independent prognostic factors are controversial. Patients with ovarian SCC and serou…