Flaws JA

No ORCID on file · 9 papers in corpus · active 2000-2025

Study types

  • article 1
  • review 1

Condition tags

  • endometriosis 1
  • infertility 1
2025
Epidemiologically relevant phthalate mixture and mono(2-ethyl-5-hydroxyhexyl) phthalate exposure alter cell energy metabolism in primary mouse granulosa cells.
Reproductive toxicology (Elmsford, N.Y.) ·doi:10.1016/j.reprotox.2025.108938

Many products including plastic food containers, medical tubing, and personal care products contain phthalate diesters. Phthalates have been shown to negatively affect the female reproductive system. However, the ovarian cellular impacts of…

2023
Chronic exposure of mice to phthalates enhances TGF beta signaling and promotes uterine fibrosis.
Reproductive toxicology (Elmsford, N.Y.) ·doi:10.1016/j.reprotox.2023.108491

Phthalates are synthetic chemicals widely used as plasticizers and stabilizers in various consumer products. Because of the extensive production and use of phthalates, humans are exposed to these chemicals daily. While most studies focus on…

2023
Ovarian volume partially explains associations of phthalate biomarkers with anti-Müllerian hormone and estradiol in midlife women.
Environment international ·doi:10.1016/j.envint.2023.107771

Background/objectivesWomen are ubiquitously exposed to endocrine disruptors, including phthalates. Ovarian follicles undergoing folliculogenesis (indirectly measured by ovarian volume) produce anti-Müllerian hormone (AMH) and estradiol (E2)…

article 2021
Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models
Advances in pharmacology (San Diego, Calif.) ·doi:10.1016/bs.apha.2021.03.008

This chapter covers the known effects of endocrine disrupting chemicals (EDCs) on reproductive disorders. The EDCs represented are highly studied, including plasticizers (bisphenols and phthalates), chemicals in personal care products (para…

2020
Exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood disrupts hormones and ovarian folliculogenesis throughout the prime reproductive life of the mouse.
Toxicology and applied pharmacology ·doi:10.1016/j.taap.2020.114952

Di(2-ethylhexyl) phthalate (DEHP) is a phthalate commonly used for its plasticizing capabilities. Because of the wide production and use of DEHP, humans are exposed to DEHP on a daily basis. Diisononyl phthalate (DiNP) is often used as a DE…

2019
Ovarian Metabolism of an Environmentally Relevant Phthalate Mixture.
Toxicological sciences : an official journal of the Society of Toxicology ·doi:10.1093/toxsci/kfz047

Phthalates are synthetic chemicals with widespread human exposure due to their use as additives in consumer products. Phthalate diesters are hydrolyzed in the environment and in the body to monoesters that may be more toxic than the parent …

2019
The epigenetic impacts of endocrine disruptors on female reproduction across generations†.
Biology of reproduction ·doi:10.1093/biolre/ioz081

Humans and animals are repeatedly exposed to endocrine disruptors, many of which are ubiquitous in the environment. Endocrine disruptors interfere with hormone action; thus, causing non-monotonic dose responses that are atypical of standard…

2019
Transgenerational Effects of Endocrine-Disrupting Chemicals on Male and Female Reproduction.
Endocrinology ·doi:10.1210/en.2019-00034

Endocrine-disrupting chemicals are known to interfere with normal reproductive function and hormone signaling. Phthalates, bisphenol A, pesticides, and environmental contaminants such as polychlorinated biphenyls and dioxins are known endoc…

review 2000
Environmental factors in infertility
Clinical obstetrics and gynecology ·doi:10.1097/00003081-200012000-00014

In conclusion, several studies indicate that there is an association between cigarette smoking and adverse reproductive outcomes in women as well as men. Some studies indicate that alcohol consumption impairs the reproductive capacity of wo…