Hareesh B. Nair
No ORCID on file
· 10 papers in corpus
2025
Midkine (MDK) is a multifunctional protein that is secreted into the extracellular space. It functions as a cytokine or growth factor, modulating a variety of signaling pathways implicated in angiogenesis, antitumor immunity, metastasis, an…
2025
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor clinical outcome. There is a dire need for the development of new targeted therapies for TNBC. Midkine (MDK), a multifunctional cytokine/growth facto…
article
2023
INTRODUCTION: The pharmacological target for progesterone, different progestins, and Selective Progesterone Receptor Modulators (SPRMs) is the nuclear progesterone receptor (PR). EC313 is a new member of a subgroup of SPRMs, mesoprogestins,…
article
2016
// Hareesh B. Nair 1 , Robert Baker 2 , Michael A. Owston 2 , Renee Escalona 2 , Edward J. Dick 2 , John L. VandeBerg 2 and Klaus J. Nickisch 1 1 Evestra, Inc., San Antonio, TX, USA 2 Southwest National Primate Research Center, Texas Biomed…
other
2013
Progesterone receptor (PR) plays a key role in reproductive functions, and compounds that inhibit progesterone action (antiprogestins) have potential use in the treatment of estrogen- and progesterone-dependent diseases, including uterine l…
article
2012
ObjectiveTo investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis.DesignIn vivo and vitro study.SettingUniversity-based academic medical center.Patient(s)Reproductive-age …
article
2012
Endometriosis is a painful gynecological condition in the fertile-age in which presence of endometrial tissue develops outside the uterus, which under normal situation found only in the inside lining of the uterus, attach to pelvic floor, e…
article
2009
Transforming growth factor beta 1 (TGF-beta1) levels are increased in the peritoneal fluid of endometriosis patients, and endometrial cells express TGF-beta signaling components; however, little is known regarding the role of TGF-beta in en…
article
2008
ObjectiveTo determine the role of peritoneal mesothelial cells (PMCs) in the process of endometrial invasion into the peritoneum and to evaluate gene expression after endometrial-PMC co-culture.DesignIn vitro study.SettingUniversity laborat…
article
2006