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Endometrial cancer (EC) incidence is rising, yet current diagnostics lack precision and scalability. We develop an artificial intelligence (AI)-based platform integrating multi-biofluid omics and clinical data for EC stratification. Using t…

OBJECTIVES: Generative artificial intelligence (generative AI) has been investigated for creating patient education materials (PEMs) to reduce the burden of clinical education and improve health information accessibility. However, prior stu…

[This corrects the article DOI: 10.3389/fendo.2025.1735567.].

STUDY QUESTION: How can the potential mechanisms and targets of endometriosis be explored through multi-omics and multi-location approaches? SUMMARY ANSWER: This exploration of the gut-reproductive axis in patients with endometriosis found…

BACKGROUND: Predicting clinical pregnancy following intrauterine insemination (IUI) remains challenging because of the complex interplay of multiple biological and treatment-related factors. Machine learning approaches may improve predictiv…

BACKGROUND: Early-life exposures may influence long-term reproductive health, but comprehensive population-based evidence remains limited. This study aimed to evaluate the associations between six early-life factors (long-term/recurrent ant…

OBJECTIVE: To evaluate rimegepant’s effectiveness and safety in the short-term prevention of pure menstrual migraine. BACKGROUND: Rimegepant’s effectiveness and safety in both acute and preventive treatment of migraine have been demonstrate…

To investigate the efficacy of different pretreatment protocols for women with endometriosis undergoing IVF. We systematically searched the Cochrane Library, PubMed, Medline, and Embase from inception to April 30, 2025, to identify randomiz…

Yao Hu,1,* Yan Chen,1,* Gaolian Li,1 Qingjing Zou,1 Jiawei Zhan,2 Dongmei Li3 1Department of Obstetrics and Gynecology, Jingzhou Central Hospital, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, People’s Republi…

OBJECTIVE: To evaluate the efficacy of intraoperative adhesion barriers in reducing long-term recurrence and alleviating pelvic pain in patients with endometriosis following laparoscopic surgery. METHODS: A retrospective analysis was perfo…

BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by chronic low-grade inflammation of the ovaries. This disorder of the immune microenvironment is closely related to abnormal follicular development and ovulation disorders. This…

OBJECTIVE: To identify the risk factors for severe primary dysmenorrhea in adolescent girls and provide evidence for clinical prevention and intervention. METHODS: This retrospective study enrolled adolescent girls with primary dysmenorrhe…

Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet…

Anxiety is heritable and exists on a continuum, with symptoms ranging from adaptive threat response to clinical disorder. Here we performed a genome-wide association meta-analysis of generalized anxiety symptom severity in 693,869 individua…

BACKGROUND AND OBJECTIVE: Ileal ureter replacement (IUR) is the definitive management approach for extensive ureteral strictures (UrSs). Patients with UrS exhibit poor health-related quality of life (HRQoL). We conducted a long-term, multi-…

BACKGROUND: Low-level sex chromosome mosaicism (SCM; abnormal cell proportion <10%) is frequently detected during preconception karyotype screening, yet its clinical relevance in assisted reproductive technology (ART) remains controversial.…

INTRODUCTION: Luteinizing hormone (LH) is critical for follicular development and IVF pregnancy outcomes, but evidence linking trigger-day serum LH levels to IVF-ET outcomes in overweight patients is scarce. This study investigated the impa…

BACKGROUND: Excessive activation of inflammatory responses and oxidative stress plays a critical role in the pathophysiology of endometriosis (EMs), which is characterized by ectopic lesion growth and chronic pelvic pain. However, effective…

Acute severe joint pain is a major symptom in gouty arthritis (GA), and its adequate treatment represents an unmet medical need. Mrgprb2, a specific mast cell receptor, has been implicated in the generation of chronic pain by mobilizing mas…

BACKGROUND: Endometriosis (EMS) is an estrogen-dependent chronic inflammatory disorder for which metabolic reprogramming has emerged as a central pathological feature. Driven by genetic, epigenetic, and microenvironmental stressors, ectopic…

Growing evidence highlights the gut, reproductive tract, and endometrial microbiota as important functional contributors in the pathogenesis of endometriosis (EM). Studies have revealed a characteristic microbial imbalance in patients with …

This study aimed to develop and validate a multimodal deep learning model that leverages 2D grayscale ultrasound (US) images alongside readily available clinical data to improve diagnostic performance for ovarian cancer (OC). A retrospectiv…

Uterine infertility is a substantial global health challenge, imposing profound physical and emotional burdens on affected individuals, with endometrial injury being a key contributing factor. In this study, we report that platelet-derived …

OBJECTIVE: This study aims to investigate the efficacy of novel embolic materials in the treatment of adenomyosis via partial embolization of uterine arteries. METHODS: From June 2023 to June 2025, we used gelatin sponge particles, liquid s…

Endometriosis is an estrogen-dependent disorder influenced by dysregulated steroidogenesis, oxidative stress, and inflammation. Bisphenol A (BPA), a common endocrine disruptor, has been associated with reproductive dysfunction, but its deve…