Blake Gilks

No ORCID on file · 5 papers in corpus · active 2010-2015

Study types

  • article 3
  • other 2

Condition tags

  • endometriosis 5
  • mesh:D004715 2
article 2015
Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden
The Journal of Pathology ·doi:10.1002/path.4516

Endometriosis is a significant risk factor for clear cell and endometrioid ovarian cancers and is often found contiguous with these cancers. Using whole-genome shotgun sequencing of seven clear cell ovarian carcinomas (CCC) and targeted seq…

other 2014
A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation
BMC cancer ·doi:10.1186/1471-2407-14-120

BACKGROUND: Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and freq…

article 2012
New Insights Into the Pathogenesis of Ovarian Carcinoma
Obstetrics and gynecology ·doi:10.1097/aog.0b013e318269b8b1

Recent discoveries about the pathogenesis of ovarian cancer have suggested that it can no longer be thought of as a single entity, but that the histologically defined ovarian cancer subtypes are different diseases, with different precursor …

other 2011
Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas
The Journal of Pathology ·doi:10.1002/path.2911

Mutation of the ARID1A gene and loss of the corresponding protein BAF250a has recently been described as a frequent event in clear cell and endometrioid carcinomas of the ovary. To determine whether BAF250a loss is common in other malignanc…

article 2010
ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
The New England journal of medicine ·doi:10.1056/nejmoa1008433

BACKGROUND: Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. METHODS: We sequenced the whole transcriptomes of 18 ovarian clear-ce…