Zhao S

BACKGROUND: Endometriosis affects up to 15% of women of reproductive age and can lead to various symptoms. More than 200 million people worldwide are at risk of higher than safe levels of arsenic exposure through drinking water. Studies inv…

BACKGROUND: Hyperuricemia (HUA) has become popular globally, being an important risk factor for various metabolic diseases. Elevated serum uric acid (UA) levels cause adverse reproductive outcomes in women with polycystic ovary syndrome und…

RESEARCH QUESTION: Can bioinformatics-driven identification of hub genes in granulosa cells be used to predict oocyte developmental potential in patients with endometriosis (EMS)-related infertility? DESIGN: This was an exploratory cohort …

BACKGROUND: Preimplantation embryos in vivo are exposed to various growth factors in the female reproductive tract that are absent in in vitro embryo culture media. Cell-free fat extract exerts antioxidant, anti-ageing, and ovarian function…

PURPOSE: This study aimed to compare the efficacy of human chorionic gonadotropin (hCG) and dual-trigger (gonadotropin-releasing hormone agonist [GnRH-a] and hCG) protocols in terms of cumulative live birth rate (CLBR) and other pregnancy o…

Uterine fibroids are common among women of reproductive age and often recur after treatment. Accurate recurrence prediction is essential for guiding clinical decisions, yet existing models remain inadequate. This study aimed to develop a no…

BACKGROUND: Ovarian cancer patients with elevated serum CA125 levels after operation have a high incidence of relapse or metastasis. 18F-FDG PET/CT is an effective imaging method for identifying recurrent or metastatic lesions. This study s…

Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communication in reproductive medicine, demonstrating considerable potential for both understanding and treating reproductive disorders. By precisely regulating…

Ferroptosis, as an iron-dependent programmed cell death, plays a significant role in reproductive system diseases. It's involved in the pathological processes of various reproductive system diseases by affecting the survival status of germ …

OBJECTIVE: To retrospectively analyze the safety and efficacy of high-intensity focused ultrasound (HIFU) combined with hysteroscopic insertion of Levonorgestrel-Releasing Intrauterine System the treatment of intrinsic adenomyosis. METHODS…

Defective endometrial receptivity represents an important factor in recurrent implantation failure (RIF), though its precise regulatory mechanisms remain unclear. While nicotinamide N-methyltransferase (NNMT) is abundantly expressed in huma…

PURPOSE: This study investigates the impact of the Chinese New Year (CNY) holiday on frozen embryo transfer (FET) outcomes in assisted reproductive technology (ART), particularly in vitro fertilization (IVF). Previous research has highlight…

RATIONALE: Ovarian cystic tumors are common in adult women. However, cases of ovarian cystic tumors approximately 30 cm in diameter are rarely reported in adult women and even rarer in children. Here, we report a rare case of a giant ovaria…

Skin cutaneous melanoma (SKCM) is a highly aggressive malignancy, and understanding the mechanisms underlying its metastasis is essential for improving patient prognosis. N6-methyladenosine (m6A) RNA modification is involved in tumor progre…

Oocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes in protein posttranslational modifications. However, the role of protein palmitoylation in oocyte aging ha…

INTRODUCTION: Intramural ectopic pregnancy (IMP) refers to the implantation and implantation of a gestational sac in the uterine muscle layer, which is a rare and potentially life-threatening disease. Early detection and diagnosis are signi…

The present study aimed to investigate the role of 6‑phosphofructo‑2‑kinase/fructose‑2,6‑biphosphatase 4 (PFKFB4) in endometrial cancer cells and to explore its potential molecular mechanisms. PFKFB4 expression in endometrial cancer tissues…

PURPOSE: A retrospective observational study was conducted to investigate the predictors for recurrence of stage I-II endometrial cancer after surgical treatment. METHODS: 130 stage I-II endometrioid carcinoma patients receiving laparoscop…

Reproductive longevity is essential for female fertility and healthy aging; however, the role of stress response, especially stress granule accumulation, in ovarian aging remains elusive and interventions are lacking. Here, we identified de…

BACKGROUND: Early spontaneous abortion (ESA) is one of the most common clinically recognized pregnancy complications. While multiple factors such as embryo abnormalities and maternal conditions may contribute to ESA, early identification an…

PURPOSE: This study was designed to evaluate the effects of dual trigger (GnRH agonist and hCG) compared with hCG trigger alone on oocyte quality, embryo development, and pregnancy outcomes in elderly women (aged≥35 years) who underwent IVF…

OBJECTIVE: This study aims to investigate alterations in immune cell counts within preovulatory follicles of patients with poor ovarian response (POR) during assisted reproductive technology (ART), classified according to the POSEIDON crite…

OBJECTIVE: Deep endometriosis is now referred to as adenomyosis externa, whereas adenomyosis is once known as endometriosis interna. Lysine-specific histone demethylase 1A (KDM1A, commonly LSD1) is a lysine demethylase that targets histone …

Pregnancy is a highly intricate and delicate process, where inflammation during early stages may lead to pregnancy loss or defective implantation. Melatonin, primarily produced by the pineal gland, exerts several pharmacological effects. N6…