Bin Yu

OBJECTIVE: To investigate the mechanisms by which Shaofu Zhuyu decoction (SFZYD, ) modulates fibrosis in a mouse model of endometriosis. METHODS: Mice were divided into control, endometriosis model, low-dose SFZYD, high-dose SFZYD, and din…

BACKGROUND: The interplay between gynaecological surgeries and arthritis pathogenesis remains poorly understood. This study offers new insights into potential health risks associated with post-hysterectomy. METHODS: The cross-sectional stu…

Shaofu Zhuyu decoction has been widely used to treat gynecological diseases; however, its mechanism of action in endometriosis remains unclear. We analyzed Shaofu Zhuyu decoction's chemical composition using ultra-high performance liquid ch…

Adiponectin is a pleiotropic cytokine predominantly derived from adipose tissue. In addition to its role in regulating energy metabolism, adiponectin may also be related to estrogen-dependent diseases, and many studies have confirmed its in…

Female infertility is a significant problem for women of reproductive age worldwide. Obesity has been proven to pose a danger for infertility in women. Weight-adjusted waist circumference index (WWI) is a recently created biomarker of obesi…

BACKGROUND AND AIM: Endometriosis (EMS) is a very complex disease with high heterogeneity. Recently, single-cell RNA sequencing (scRNA-seq) has been applied to comprehensively characterize cellular heterogeneity. Here, we built a new transc…

BACKGROUND: Recurrent implantation failure (RIF) is a major limitation of assisted reproductive technology, which is associated with impaired endometrial receptivity. Although N6-methyladenosine (m6A) has been demonstrated to be involved in…

BACKGROUND: Gastric cancer (GC) is one of the major public health problems worldwide with high morbidity and mortality. Nowadays, traditional medicine may hold promise for the treatment of cancers. Gossypol-acetic acid (GAA) is a male contr…

The poor prognosis and fewer treatment option is a current clinical challenge for patients with lung adenosquamous carcinoma (ASC). The previous studies reported that tumor mutational burden (TMB, numbers of mutation per Megabase) is a pred…

BACKGROUND: The transcription factor Snail2 is a repressor of E-cadherin expression during carcinogenesis; however, the specific mechanisms involved in this process in human colorectal cancer (CRC) remain largely unknown. METHOD: We checke…

[Objective] To explore a method d isolating and culturing eutopic endometrial stromal cells,providing an in vitro cell model of adenomyosis for study of its mechanism.[Methods] Enzymolysis,filtration,sedimentation and pasted wall purificati…

Purpose To investigate the clinical effect of the use of leuprolide after laparoscopic surgery in patients with endometriosis. Method: Select 220 patients with endometriosis treated in our hospital from January 2015 to June 2016, and rando…