BRIDGES Alexander James

The invention relates to compounds represented by formula I: which are irreversible inhibitors of tyrosine kinazes, to pharmaceutiyal compositions containing the same and to the use thereof in the treatment of cancer, atherosclerosis, reste…

The invention relates to compounds represented by formula I: which are irreversible inhibitors of tyrosine kinazes, to pharmaceutiyal compositions containing the same and to the use thereof in the treatment of cancer, atherosclerosis, reste…

The invention relates to compounds represented by formula I: which are irreversible inhibitors of tyrosine kinazes, to pharmaceutiyal compositions containing the same and to the use thereof in the treatment of cancer, atherosclerosis, reste…

The invention relates to compounds represented by formula I: which are irreversible inhibitors of tyrosine kinazes, to pharmaceutiyal compositions containing the same and to the use thereof in the treatment of cancer, atherosclerosis, reste…

The invention relates to compounds represented by formula I: which are irreversible inhibitors of tyrosine kinazes, to pharmaceutiyal compositions containing the same and to the use thereof in the treatment of cancer, atherosclerosis, reste…

The invention relates to compounds represented by formula I: which are irreversible inhibitors of tyrosine kinazes, to pharmaceutiyal compositions containing the same and to the use thereof in the treatment of cancer, atherosclerosis, reste…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro- phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylami…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro- phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylami…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro- phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylami…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro- phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylami…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro- phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylami…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro- phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylami…

A method of treating cancer such as breast cancer or colon cancer, comprising administer to a non-human patient having cancer a therapeutically effective amount of the compound N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propox…

A method of treating cancer such as breast cancer or colon cancer, comprising administer to a non-human patient having cancer a therapeutically effective amount of the compound N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propox…

A method of treating cancer such as breast cancer or colon cancer, comprising administer to a non-human patient having cancer a therapeutically effective amount of the compound N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propox…

A method of treating cancer such as breast cancer or colon cancer, comprising administer to a non-human patient having cancer a therapeutically effective amount of the compound N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propox…

A method of treating cancer such as breast cancer or colon cancer, comprising administer to a non-human patient having cancer a therapeutically effective amount of the compound N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propox…

A method of treating cancer such as breast cancer or colon cancer, comprising administer to a non-human patient having cancer a therapeutically effective amount of the compound N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propox…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamid…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamid…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamid…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamid…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamid…

Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula (1) are disclosed. Such inhibitors, which include N-[4-)3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamid…

The present invention provides compounds that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that …