Yasushi Hirota

The association between adenomyosis and uterine torsion, a rare, serious obstetric condition, remains unclear and has not been systematically investigated. This study aimed to elucidate the incidence, risk factors, and clinical characterist…

BACKGROUND: Recurrent implantation failure (RIF) is an infertility condition in which uterine factors remain difficult to diagnose and treat. Recent studies implicate the endometrial microbiome in implantation. METHODS: This clinically ori…

RESEARCH QUESTION: Does adenomyosis increase the risk of thromboembolic events, including both arterial and venous thromboembolism, compared with endometriosis, and what clinical factors may contribute to this association? DESIGN: This ret…

PURPOSE: This study aimed to develop international expert consensus statements on chronic endometritis (CE) through a comprehensive literature review of existing evidence and a modified Delphi approach. METHODS: Ten panelists of the Japan …

Objective To evaluate the long-term impact of postoperative oral contraceptive (OC) recommendation after laparoscopic cystectomy endometrioma on the incidence of endometrioma recurrence and ovarian cancer development. Material and methods T…

Abstract Background: The implantation (retrograde menstruation) theory hypothesizes that endometriosis arises when refluxed endometrial cells implant at ectopic sites; however, a fallopian tube epithelial origin has also been proposed. …

BACKGROUND: We aimed to evaluate the risk of perinatal complications in subsequent pregnancies after different types of myomectomy, viz. open, laparoscopic, or hysteroscopic. Moreover, we investigated whether the time interval from myomecto…

Ovarian clear cell carcinoma (OCCC) is a chemoresistant subtype of epithelial ovarian cancer with limited therapeutic options and distinct molecular features. Histone methyltransferase SETD8 catalyzes the monomethylation of histone H4 at ly…

The reproductive tract microbiome plays a pivotal role in female fertility, with Lactobacillus-dominated communities maintaining a protective, low-pH environment. Dysbiosis-characterized by a reduction in Lactobacillus species and overgrowt…

Adenomyosis is an intractable gynecological disorder that can give rise to severe pelvic pain, heavy menstrual bleeding, and infertility, predominantly affecting women of reproductive age. The limited efficacy of current pharmacological int…

Tokishakuyakusan (TSS), a traditional Japanese Kampo medicine, is known for its anti-inflammatory and anti-angiogenic properties. This study examined the effects of TSS on fecundity and endometriosis-like lesions during pregnancy in a murin…

BACKGROUND: Despite advances in assisted reproductive technology (ART), embryo implantation remains inefficient and represents a major barrier to successful pregnancy. Recurrent implantation failure persists even after transfer of high-qual…

PURPOSE: Recurrent implantation failure (RIF) is a form of refractory infertility that persists despite assisted reproductive technology. Cine magnetic resonance imaging (cine MRI) enables the visualization of uterine peristalsis; however, …

BACKGROUND: Women's health is significantly influenced by the appropriate and timely secretion of female sex steroid hormones. Consequently, awareness of hormonal fluctuations at various life stages is crucial. In 2016, the Japanese Ministr…

BACKGROUND: The age-related decline of fertility is caused by a reduction of the ovarian reserve, which is represented by the number and quality of oocytes in the ovaries. Anti-Müllerian hormone (AMH) is considered one of the most useful ma…

BACKGROUND: With the increasing incidence of autism spectrum disorder (ASD), various risk factors for ASD have been identified. Among them, maternal immune activation (MIA), which can be triggered by inflammation via elevated proinflammator…

Although ovarian endometrioid carcinoma (OEC), frequently associated with endometrial endometrioid carcinoma (EEC), is often diagnosed at an early stage, the prognosis remains poor. The development of new, effective drugs to target these ca…

Patients with endometriosis are at a high risk of developing pelvic inflammatory disease. This case series presents three cases of colo-ovarian fistulas associated with endometriosis, highlighting the potential for conservative management i…

Chronic endometritis (CE) and endometrial dysbiosis (ED) are major causes of recurrent implantation failure (RIF). CE is diagnosed via hysteroscopy or the endometrial CD138 test; ED is examined using endometrial microbiome testing with next…

OBJECTIVE: Intestinal disorders (ID) impose a significant burden on preterm infants. Although previous studies have examined individual risk factors for types of ID such as necrotizing enterocolitis (NEC), meconium-related ileus (MRI), and …

Assisted hatching (AH) is a reproductive technique that artificially thins or breaches the zona pellucida to facilitate hatching. Despite its widespread use, there is insufficient evidence to conclude that AH improves pregnancy outcomes, pa…

PURPOSE: This study evaluated whether embryo cryopreservation before surgery (ECBS) improves clinical outcomes in in vitro fertilization (IVF) patients with endometrioma. METHODS: This retrospective study included patients aged 28-42 years…

RESEARCH QUESTION: How significant is the impact of dysmenorrhea on work productivity and quality of life (QoL) among Japanese women?. METHODS: This large-scale cross-sectional study was conducted using a web-based self-report questionnair…

Adenomyomectomy, a therapeutic option for women with adenomyosis who wish to preserve their fertility, has been reported to pose a risk of developing placenta accreta spectrum (PAS) and uterine rupture in future pregnancies. However, the sp…