Zhang J

OBJECTIVE: To investigate the association between lipid accumulation product (LAP) and endometriosis using data from the National Health and Nutrition Examination Survey (NHANES), because lipid metabolism alterations and obesity have been i…

BACKGROUND: Accurate prediction of pregnancy outcomes in assisted reproductive technology (ART) remains a clinical challenge due to the complexity and heterogeneity of IVF/ICSI cycles. Existing models often focus on isolated treatment stage…

The periconception period is critical for embryo development, pregnancy outcomes, and offspring health. During this stage, oviductal and uterine fluids facilitate embryo-maternal interactions and support early embryonic development. Using P…

OBJECTIVES: To investigate the mechanism of medicinal cake-separated moxibustion in inhibiting the adhesion, invasion and angiogenesis of ectopic endometriotic tissues in endometriosis (EMs) rats through transforming growth factor-β1 (TGF-β…

Adenomyosis, a prevalent gynecologic disorder affecting women of reproductive age, is characterized by the presence of ectopic endometrial tissue within the myometrium. The involvement and underlying mechanisms of ferroptosis in adenomyosis…

BACKGROUND: Endometrial cancer (EC), a type of uterine cancer, is witnessing a global increase in incidence. Despite advancement in diagnosis and treatment, metastatic or recurrent EC often exhibits a poor prognosis, necessitating novel the…

We report two cases of heterotopic intramural ectopic pregnancy (HIMP) following multiple abortions, with lesions located near the uterine fundus or uterine horn. These cases are particularly challenging to diagnose using early two-dimensio…

Mitochondria, the powerhouse of the cell, orchestrate a plethora of critical functions, including energy production, metabolic regulation, programmed cell death, and signal transduction. Their pivotal role in the pathogenesis of numerous di…

Diabetes-associated infertility results from interconnected immunometabolic, oxidative, inflammatory, and endocrine disturbances that impair reproductive function in both sexes. Conventional therapies address individual symptoms but often f…

Natural killer (NK) cells, serving as pivotal mediators of innate immunity, play an important role in antitumor immunity. Immune checkpoint can be expressed on the surface of NK cells and meticulously regulates their activation states and e…

Rationale: Endometriosis, characterized by the presence of ectopic endometrial-like tissue, is a common chronic inflammatory disorder in gynecology. However, current treatments, including surgery and hormone therapy, often yield suboptimal …

INTRODUCTION: Dynamic changes in adenomyotic lesions in animal models have been difficult to observe and evaluate in vivo on a regular basis. Therefore, this study aims to investigate the feasibility of establishing a rat model of adenomyos…

Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of adverse fetal outcomes, including fetal morbidity and mortality. It is a complex liver disorder influenced by genetic interactions, estrogen levels, and env…

BACKGROUND: To date, there is no consensus on the optimal endometrial preparation protocol for frozen-thawed embryo transfer (FET) in patients with a thin endometrium. This study evaluated the effects of different endometrial preparation pr…

Fibrosis constitutes the principal pathophysiological mediator of pain and infertility manifestations in endometriosis, and the inhibitory factor of the TGF-β pathway, MADH7, makes a vital impact on the progression of fibrosis. Ovarian tumo…

Premature ovarian insufficiency (POI) is one of the most common diseases contributing to declining fertility globally. Autoimmune dysregulation has been implicated in POI, but the role of B cell and its subsets in immune dysregulation in PO…

Adenomyosis is a common gynecological condition affecting women of reproductive age, posing significant diagnostic challenges due to its diverse clinical presentations. This extended opinion study critically reviews the diagnostic methods f…

PURPOSE: To investigate and compare the clinical characteristics and risk factors between intrinsic and extrinsic adenomyosis (AM), as well as the differences in their perioperative management and findings in the two subtypes. METHODS: Thi…

BACKGROUND: Insulin resistance(IR) is a key mechanism underlying both obesity and metabolic syndrome, with significant implications for the onset and progression of female infertility. This study systematically examines the associations bet…

BACKGROUND: To investigate the optimal periendometrial zone (PEZ) in ultrasound (US) images and assess the performance of ultrasound radiomics in predicting the outcome of frozen embryo transfer (FET). METHODS: This prospective study had 4…

BACKGROUND: Preimplantation genetic testing for chromosomal structural rearrangements (PGT-SR) has been widely utilized to select euploid embryos in patients carrying balanced chromosomal rearrangements (BCRs) by chromosome copy number anal…

BACKGROUND: Fear of childbirth is a common concern among pregnant women, potentially affecting maternal physical and mental health as well as birth outcomes. However, the factors influencing fear of childbirth are still being explored. This…

INTRODUCTION: A symptomatic uterine niche is a long-term complication after a cesarean section (CS). A group of international niche experts reached consensus on a standardized definition of a disorder caused by a symptomatic niche, named ce…

Primary antiphospholipid syndrome (APS) is an autoimmune thrombophilic disorder characterized by recurrent venous or arterial thrombosis and/or pregnancy morbidity in the presence of persistent antiphospholipid antibodies (aPL). Renal invol…

Retroperitoneal squamous cell carcinoma (SCC) is an extremely rare tumor originating from the retroperitoneum, with an unclear etiology and origin. Imaging studies are the preferred diagnostic modality for retroperitoneal tumors. The presen…