Rossella E. Nappi

OBJECTIVE: Since its introduction 50 years ago, the contraceptive pill has continuously evolved to decrease the risk of venous thromboembolism (VTE) associated with its use. An increased risk of VTE still remains, however. Other concerns, s…

ObjectivesTo evaluate the impact of a 91-day extended regimen combined oral contraceptive (150 μg levonorgestrel [LNG]/30 μg ethinylestradiol [EE] for 84 days, followed by 10 μg EE for seven days [Treatment 1]) compared with two traditional…

Combined oral contraceptives formulated to include estradiol (E2) have recently become available for the indication of pregnancy prevention. A combined estradiol valerate and dienogest pill (E2V/DNG), designed to be administered using an es…

ObjectiveTo investigate the amount of perceived stress in a group of women with different forms of endometriosis-related pain before and after surgical treatment.DesignProspective clinical trial.SettingUniversity hospital.Patient(s)A group …

BackgroundCombined hormonal contraception might worsen migraine in sensitive women, especially during the free-hormone interval, and raise concerns about the vascular risk. The characteristics of a contraceptive pill containing estradiol va…

ObjectivesCLOSER investigated how postmenopausal vaginal atrophy ('vaginal discomfort') affects relationships between women and their partners.Study designCLOSER involved postmenopausal women (55-65 years) with vaginal discomfort, and male …

INTRODUCTION: Dyspareunia and sexual dysfunction are common in women with urological disorders. The study of comorbidity between interstitial cystitis (IC) and vulvodynia seems to be relevant to understand the mechanism generating pain in t…

Considerable advances have been made in hormonal contraception in recent years, geared at maximizing compliance and minimizing discontinuation. In oral contraceptive (OC) formulations, the estrogenic component, generally ethinyl estradiol (…