Sharma A

Endometriosis is a chronic, incurable disease. Due to limited efficacy, high recurrence rates, and serious side effects of current treatments, development of new, targeted, non-hormonal therapies is urgently needed. We previously reported t…

Introduction Melasma is a common condition seen in dermatology clinics and is considered to be a multifactorial disease. We designed the present study to: study the factors associated with melasma (including metabolic syndrome (MetS) and bi…

BackgroundIntrauterine insemination (IUI) is a popular method for the treatment of infertility, however, its success rate ranges from 7 to 13% in a cycle.AimThe present study was carried out to assess the IUI success rate and its predictors…

Endometriosis is a gynecological condition characterized by the presence of endometrial-like tissue outside the uterus, typically at sites including the ovary, uterosacral ligaments, ovarian fossa, the pouch of Douglas, and the bladder, tho…

Dedifferentiated carcinoma of the ovary (DDOC) is a rare and aggressive malignancy characterized by both differentiated and undifferentiated carcinoma components. While its endometrial counterpart, dedifferentiated carcinoma of the endometr…

Background and objectiveDysmenorrhea is common among young women and adversely affects daily activities and academic performance. Concerns regarding long-term use of analgesics have increased reliance on complementary and alternative therap…

This study investigated how chronic pelvic pain (CPP) develops using rhesus macaques with naturally occurring endometriosis and a multiple lesion induction mouse model (MIM), as repeated retrograde menstruation is considered an underlying m…

Background: Hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSDs) are prevalent, complex conditions marked by chronic pain, joint instability, and multisystem involvement. Despite affecting an estimated 1 in …

The intricate ecosystem of the gut microbiome exhibits sex-specific differences, influencing the susceptibility to cardiovascular diseases (CVD). Imbalance within the gut microbiome compromises the gut barrier, activates inflammatory pathwa…

IntroductionBladder pain syndrome/Interstitial cystitis (BPS/IC) is clinically of diverse types because different causes contribute to the development of their symptoms. It is important to classify patients into various groups based on the …

Background: The interplay between breast cancer treatment and osteoporosis has important consequences for anticancer therapy and patient bone health. Many breast cancer therapies involve hormonal treatments that lower estrogen levels, which…

Inflammation is the defense mechanism of the immune system against harmful stimuli such as pathogens, toxic compounds, damaged cells, radiation, etc., and is characterized by tissue redness, swelling, heat generation, pain, and loss of tiss…

BackgroundThe purpose of the study was to determine the cut-off values for peripheral and uterine natural killer (pNK, uNK) cells in fertile controls and in women with recurrent implantation failure (RIF).MethodsIn this study, 50 women with…

IntroductionPhysical exercise deters the risk and reduce the adjusted Odds Ratio related to obesity and cardiometabolic diseases but the amount of physical exercise required for initiating those potential advantageous developments in the hu…

Ovarian cancer (OVCA) is the second most common gynecological cancer and one of the leading causes of cancer related mortality among women. Recent studies suggest that among ovarian cancer patients at least 70% of the cases experience the i…

INTRODUCTION: Heterogeneous and nonspecific symptoms make invasive endometriosis a difficult entity to diagnose. Small lesions with absent associated changes can be easily missed in cross-sectional imaging. Even when the lesions satisfy the…

BackgroundOur study aimed to establish 'real-world' performance and cost-effectiveness of ovarian cancer (OC) surveillance in women with pathogenic germline BRCA1/2 variants who defer risk-reducing bilateral salpingo-oophorectomy (RRSO).Met…

Undifferentiated pleomorphic sarcoma (UPS) previously called as malignant fibrous histiocytoma comprises a group of high-grade pleomorphic sarcomas that cannot be otherwise classified and considered as a diagnosis of exclusion. In the head …

BackgroundInfertility is a very distressing condition. It is often associated with long-term stress, which can emerge as anxiety and depression.AimTo understand the effect of socio-demographic variables, reproductive trajectories, and lifes…

IntroductionHysterectomy is the most common gynaecological operation worldwide. The objective of the study is to analyze the various routes of hysterectomy and its complications when the decision of route is based on using a prospective alg…

ObjectiveTo investigate the association between hysterectomy with conservation of one or both adnexa and ovarian and tubal cancer.DesignProspective cohort study.SettingThirteen NHS Trusts in England, Wales and Northern Ireland.PopulationA t…

Case summaryA 27 years old female presented to gynae OPD with foul smelling discharge per vaginum off and on for a year and was given treatment for PID (Pelvic inflammatory disease) and cervicitis. Pap smear was taken and was reported unsat…

Intestinal-type adenocarcinoma is a rare primary vaginal carcinoma. Vaginal adenocarcinomas are most frequently a metastatic lesion, and less commonly, have clear cell histology and occur in young women with diethylstilbestrol (DES) exposur…