Rosner BA

PurposeCirculating levels of sex steroid hormones have previously been associated with premenopausal breast cancer risk. Few studies have considered the association between dietary patterns and premenopausal hormone levels. Our objective wa…

ObjectiveTo evaluate the association between parity and breastfeeding and anti-Müllerian hormone levels (AMH) and change in AMH levels over time. Furthermore, we examined whether AMH levels mediate the relation of parity and breastfeeding w…

ImportanceBreastfeeding has been associated with a reduced risk of epithelial ovarian cancer in multiple studies, but others showed no association. Whether risk reduction extends beyond that provided by pregnancy alone or differs by histoty…

Early natural menopause, the cessation of ovarian function prior to age 45 years, affects approximately 10% of women and increases risk of cardiovascular disease and other adverse conditions. Laboratory evidence suggests a potential role of…

BackgroundCancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal charac…

BACKGROUND: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, thi…

ImportanceOvarian cancer is a highly fatal malignant neoplasm with few modifiable risk factors. Case-control studies have reported a modest reduced risk of ovarian cancer among women who frequently use aspirin or regularly use low-dose aspi…

PurposeOral contraceptives (OCs) have been consistently associated with a reduced ovarian cancer risk; however, most previous studies included women in older birth cohorts using high-dose OC formulations. We assessed OC use, including type …

Background: Early menopause, defined as the cessation of ovarian function before the age of 45 y, affects ∼10% of women and is associated with higher risk of cardiovascular disease, osteoporosis, and other conditions. Few modifiable risk fa…

BACKGROUND: Ovarian cancer survival is poor, particularly for platinum-resistant cases. The previous literature on pre-diagnostic reproductive factors and ovarian cancer survival has been mixed. Therefore, we evaluated pre-diagnostic reprod…

ObjectiveWe assessed the association between reproductive and hormonal factors and ovarian cancer incidence characterized by estrogen receptor-α (ERα) and progesterone receptor (PR) status.MethodsTissue microarrays were used to assess ERα a…

ObjectiveTo determine whether use of oral contraceptives is associated with all cause and cause specific mortality.DesignProspective cohort study.SettingNurses' Health Study, data collected between 1976 and 2012.Population121,701 participan…

BackgroundThe surface epithelial glycoprotein MUC1 becomes overexpressed and hypoglycosylated in adenocarcinomas; similar changes occur during nonmalignant inflammatory events. Antibodies developed against tumor-like MUC1 in response to suc…

ObjectiveTo evaluate whether the amount or quality of carbohydrate in diet is associated with ovulatory infertility.Subjects and methodsIn total, 18,555 married, premenopausal women without a history of infertility were followed as they att…

BackgroundMany studies have examined whether caffeine, alcohol, or specific beverages containing these substances affect fertility in women. However, most of these studies have retrospectively collected information on alcohol and caffeine i…

ObjectiveThe objective of the study was to evaluate whether intake of protein from animal and vegetable origin is associated with ovulatory infertility.Study designA total of 18,555 married women without a history of infertility were follow…

ObjectiveTo examine whether use of multivitamins and intake of specific nutrients in multivitamins is associated with ovulatory infertility.DesignA prospective cohort study.SettingThe Nurses' Health Study II.Patient(s)Eighteen thousand five…