Louis Muglia — Endo Lab

lab-animal 2024

A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis

Nature communications ·doi:10.1038/s41467-024-45338-4

The common human SNP rs3820282 is associated with multiple phenotypes including gestational length and likelihood of endometriosis and cancer, presenting a paradigmatic pleiotropic variant. Deleterious pleiotropic mutations cause the co-occ…

lab-animal 2022

A SNP affects Wnt4 expression in endometrial stroma, with antagonistic implications for pregnancy, endometriosis and reproductive cancers

·doi:10.1101/2022.10.25.513653

Abstract The common human single nucleotide polymorphism rs3820282 is associated with multiple phenotypes ranging from gestational length to likelihood of endometriosis and ovarian cancer and can thus serve as a paradigm for a highly pleiot…

other 2020

Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth

Science advances ·doi:10.1126/sciadv.abc8696

While a genetic component of preterm birth (PTB) has long been recognized and recently mapped by genome-wide association studies (GWASs), the molecular determinants underlying PTB remain elusive. This stems in part from an incomplete availa…

meta-analysis 2019

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

Nature communications ·doi:10.1038/s41467-019-11881-8

The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 in…