Keku TO

No ORCID on file · 4 papers in corpus · active 2019-2023
2023
The interplay of obesity, microbiome dynamics, and innovative anti-obesity strategies in the context of endometrial cancer progression and therapeutic approaches.
Biochimica et biophysica acta. Reviews on cancer ·doi:10.1016/j.bbcan.2023.189000

Endometrial cancer (EC) is the most common gynecologic malignancy in the United States, and its incidence and mortality are rising. Obesity is more tightly associated with EC than any other cancer. Thus, the rising prevalence of obesity and…

2022
An evaluation of the microbiota of the upper reproductive tract of women with and without epithelial ovarian cancer.
Gynecologic oncology reports ·doi:10.1016/j.gore.2022.101017

ObjectiveThe microbiome of the female upper reproductive tract (URT) has not been characterized. We hypothesize that distinct bacterial species may be identified in different areas of the URT in women with or without ovarian cancers.Methods…

2022
Differences in the microbial profiles of early stage endometrial cancers between Black and White women.
Gynecologic Oncology ·doi:10.1016/j.ygyno.2022.02.021

ObjectiveBlack women suffer a higher mortality from endometrial cancer (EC) than White women. Potential biological causes for this disparity include a higher prevalence of obesity and more lethal histologic/molecular subtypes. We hypothesiz…

2019
Discovery of common and rare genetic risk variants for colorectal cancer.
Nature genetics ·doi:10.1038/s41588-018-0286-6

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome…