Biochimica et biophysica acta. Reviews on cancer

2024

ASPORIN: A root of the matter in tumors and their host environment.

doi:10.1016/j.bbcan.2023.189029 ·PMID:38008263

Asporin (ASPN) has been identified as one of the members of the class I small leucine-rich proteoglycans (SLRPs) family in the extracellular matrix (ECM). It is involved in classic ensigns of cancers such as self-dependent growth, resistanc…

2023

Lymphatic vasculature in ovarian cancer.

doi:10.1016/j.bbcan.2023.188950 ·PMID:37419192

Ovarian cancer (OVCA) is the second most common gynecological cancer and one of the leading causes of cancer related mortality among women. Recent studies suggest that among ovarian cancer patients at least 70% of the cases experience the i…

2023

The interplay of obesity, microbiome dynamics, and innovative anti-obesity strategies in the context of endometrial cancer progression and therapeutic approaches.

doi:10.1016/j.bbcan.2023.189000 ·PMID:37844671

Endometrial cancer (EC) is the most common gynecologic malignancy in the United States, and its incidence and mortality are rising. Obesity is more tightly associated with EC than any other cancer. Thus, the rising prevalence of obesity and…

2021

Altered glycosylation in cancer: A promising target for biomarkers and therapeutics.

doi:10.1016/j.bbcan.2020.188464 ·PMID:33157161

Glycosylation is a well-regulated cell and microenvironment specific post-translational modification. Several glycosyltransferases and glycosidases orchestrate the addition of defined glycan structures on the proteins and lipids. Recent adv…