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BACKGROUND: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder associated with both reproductive and metabolic dysregulation. While anti-Müllerian hormone (AMH) and the triglyceride-glucose (TyG) index have been independ…

OBJECTIVE: To evaluate and compare the efficacy of tubal reanastomosis and in vitro fertilisation in achieving reproductive success in women who had undergone tubal ligation and desired additional children. METHODS: This study included 152…

BACKGROUND: The impact of long-acting reversible contraception (LARC) on female sexual function remains a controversial and often overlooked issue. This study aimed to evaluate the effects of three common LARC methods on female sexual funct…

Diminished ovarian reserve (DOR) is characterized by a decline in oocyte quantity and/or quality and represents a growing cause of female infertility, particularly among young women, yet its pathogenesis remains incompletely understood. Dis…

OBJECTIVE: To systematically evaluate the associations between paternal factors (age, semen parameters, body mass index, sperm DNA fragmentation index (DFI), and leukocyte count), embryonic ploidy, and the clinical implantation potential of…

PURPOSE: To investigate the hypothesis that an imbalance between the epithelial adhesion molecule E-cadherin and matrix metalloproteinases (MMPs) underlies the vaginal atrophy associated with menopause. METHODS: This cross-sectional study …

OBJECTIVES: To evaluate the efficacy of gonadotropin-releasing hormone agonist (GnRHa) combined with lauromacrogol sclerotherapy in preserving ovarian reserve and reducing pain in patients with ovarian endometriotic cysts (OECs). MATERIALS…

Infertility remains a global challenge, with female factors accounting for the majority of cases. Endometrial receptivity (ER), the ability of the endometrium to accept and support embryo implantation, is a critical determinant of successfu…

BACKGROUND: Threatened abortion is a common obstetric complication where early risk stratification is crucial for clinical management. CA125, a glycoprotein biomarker produced by endometrial and trophoblastic tissues, may serve as a valuabl…

BACKGROUND: Few previous studies have addressed the impact of COVID-19 infection status on assisted reproductive technology outcomes. The purpose of this study was to assess whether COVID-19 infection affects ovulation induction outcomes an…

DNA methylation is a common endogenous chemical modification in eukaryotic DNA, primarily involving the covalent attachment of a methyl group to the fifth carbon of cytosine residues, leading to the formation of 5-methylcytosine (5mC). This…

Vaginitis is the most common problem afflicting women of childbearing age. However, the underlying etiological factors remain poorly understood, leading to recurrent vaginitis and constraining clinical management. Here, we explored whether …

Progressive dysmenorrhea and extensive fibrosis within the myometrium are hallmark features of adenomyosis (AM). Approximately 80% of patients with AM experience secondary dysmenorrhea, which occurs more frequently in AM than in other gynec…

SALL1 is a critical regulator of embryonic development across a wide swath of tissues, including vital organs, but little is known about its function in adult tissues. Recent work from our group demonstrates that SALL1 is involved in urogen…

OBJECTIVE: Explored the risk factors for venous thromboembolism in gynecological inpatients in western China, and developed an improved model to predict the VTE of this patient population. METHODS: The records of 6897 patients hospitalized…

SIGNIFICANCE: Minimally invasive surgery (MIS) has shown vast improvement over open surgery by reducing post-operative stays, intraoperative blood loss, and infection rates. However, in spite of these improvements, there are still prevalent…

The present study aimed to investigate the efficacy of hysteroscopic levonorgestrel-releasing intrauterine device (LNG-IUD) fixation surgery in the treatment of adenomyosis through a cohort study. The cohort study was performed at the Affil…

The composite dietary antioxidant index (CDAI) serves as a valuable instrument for evaluating the intake of dietary antioxidants. This research aims to clarify the connection between CDAI and the risk of female infertility by analyzing data…

To evaluate whether RNA-seq-based endometrial receptivity testing (rsERT) can improve pregnancy outcomes in personalized frozen-thawed embryo transfer (pFET) during hormone replacement therapy (HRT) cycles among patients with recurrent impl…

BACKGROUND: Fibrogenesis within ovarian endometrioma (endometrioma), mainly induced by transforming growth factor-β (TGF-β), is characterized by myofibroblast over-activation and excessive extracellular matrix (ECM) deposition, contributing…

The goal of the study was to explore the mechanism underlying the progression from abnormal uterine bleeding with ovulatory dysfunction (AUB-O) to AUB with atypical hyperplasia/malignancy (AUB-M). AUB-O, AUB-M and control endometrial tissue…

During the secretory phase of the menstrual cycle, endometrial fibroblast cells begin to change into large epithelial-like cells called decidual cells in a process called decidualization. This differentiation continues more broadly in the e…

Endometrial fibrosis is the histologic appearance of intrauterine adhesion (IUA). Emerging evidences demonstrated umbilical cord mesenchymal stem cell-derived exosomes (UCMSC-exo) could alleviate endometrial fibrosis. But the specific mecha…

Severe endometrium damage causes pathological conditions such as thin endometrium and intrauterine adhesion, resulting in uterine factor infertility. Mesenchymal stem cell (MSC) therapy is a promising strategy in endometrial repair; yet, ex…