Barry V L Potter

No ORCID on file · 4 papers in corpus · active 2015-2021

Study types

  • other 2
  • review 2

Condition tags

  • endometriosis 4
other 2021
N-Phenyl-1,2,3,4-tetrahydroisoquinoline: An Alternative Scaffold for the Design of 17β-Hydroxysteroid Dehydrogenase 1 Inhibitors
ChemMedChem ·doi:10.1002/cmdc.202000762

17β-Hydroxysteroid dehydrogenases catalyse interconversion at the C17 position between oxidized and reduced forms of steroidal nuclear receptor ligands. The type 1 enzyme, expressed in malignant cells, catalyses reduction of the less-active…

review 2018
SULFATION PATHWAYS: Steroid sulphatase inhibition via aryl sulphamates: clinical progress, mechanism and future prospects
Journal of molecular endocrinology ·doi:10.1530/JME-18-0045

Steroid sulphatase is an emerging drug target for the endocrine therapy of hormone-dependent diseases, catalysing oestrogen sulphate hydrolysis to oestrogen. Drug discovery, developing the core aryl O-sulphamate pharmacophore, has led to st…

other 2015
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health
Journal of medicinal chemistry ·doi:10.1021/acs.jmedchem.5b00386

In 1994, following work from this laboratory, it was reported that estrone-3-O-sulfamate irreversibly inhibits a new potential hormone-dependent cancer target steroid sulfatase (STS). Subsequent drug discovery projects were initiated to dev…

review 2015
Estrogen O-sulfamates and their analogues: Clinical steroid sulfatase inhibitors with broad potential
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2015.03.012

Estrogen sulfamate derivatives were the first irreversible active-site-directed inhibitors of steroid sulfatase (STS), an emerging drug target for endocrine therapy of hormone dependent diseases that catalyzes inter alia the hydrolysis of e…