Mathew P Leese

No ORCID on file · 1 paper in corpus · active 2021

Study types

  • other 1

Condition tags

  • endometriosis 1
other 2021
N-Phenyl-1,2,3,4-tetrahydroisoquinoline: An Alternative Scaffold for the Design of 17β-Hydroxysteroid Dehydrogenase 1 Inhibitors
ChemMedChem ·doi:10.1002/cmdc.202000762

17β-Hydroxysteroid dehydrogenases catalyse interconversion at the C17 position between oxidized and reduced forms of steroidal nuclear receptor ligands. The type 1 enzyme, expressed in malignant cells, catalyses reduction of the less-active…