Barrett JH

ORCID: 0000-0002-1720-7724 · 4 papers in corpus
lab-animal 2020
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma
Nature communications ·doi:10.1038/s41467-020-16590-1

Genome-wide association studies (GWAS) have identified ~20 melanoma susceptibility loci, most of which are not functionally characterized. Here we report an approach integrating massively-parallel reporter assays (MPRA) with cell-type-speci…

observational 2014
The effect on melanoma risk of genes previously associated with telomere length
Journal of the National Cancer Institute ·doi:10.1093/jnci/dju267

Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 111…

observational 2013
Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk
Carcinogenesis ·doi:10.1093/carcin/bgs407

Genome-wide association studies (GWASs) have mainly focused on top significant single nucleotide polymorphisms (SNPs), most of which did not have clear biological functions but were just surrogates for unknown causal variants. Studying SNPs…

observational 2011
Genome-wide association study identifies novel loci predisposing to cutaneous melanoma
Human molecular genetics ·doi:10.1093/hmg/ddr415

We performed a multistage genome-wide association study of melanoma. In a discovery cohort of 1804 melanoma cases and 1026 controls, we identified loci at chromosomes 15q13.1 (HERC2/OCA2 region) and 16q24.3 (MC1R) regions that reached genom…