Chen WV

No ORCID on file · 5 papers in corpus · active 2011-2017
2017
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
JAMA oncology ·doi:10.1001/jamaoncol.2016.5945

ImportanceThe causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causati…

2015
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.
Nature genetics ·doi:10.1038/ng.3373

Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis…

2013
Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk.
Carcinogenesis ·doi:10.1093/carcin/bgs407

Genome-wide association studies (GWASs) have mainly focused on top significant single nucleotide polymorphisms (SNPs), most of which did not have clear biological functions but were just surrogates for unknown causal variants. Studying SNPs…

2013
Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.
Pigment cell & melanoma research ·doi:10.1111/pcmr.12069

To mine possibly hidden causal single-nucleotide polymorphisms (SNPs) of melanoma, we investigated the association of SNPs in 76 M/G1 transition genes with melanoma risk using our published genome-wide association study (GWAS) data set with…

2011
Genome-wide association study identifies novel loci predisposing to cutaneous melanoma.
Human molecular genetics ·doi:10.1093/hmg/ddr415

We performed a multistage genome-wide association study of melanoma. In a discovery cohort of 1804 melanoma cases and 1026 controls, we identified loci at chromosomes 15q13.1 (HERC2/OCA2 region) and 16q24.3 (MC1R) regions that reached genom…