Chen Z

BackgroundCervical squamous cell carcinoma (CESC) constitutes a substantial global health burden, especially in resource-limited regions. The identification of reliable biomarkers is critical for developing a clinically applicable nomogram …

Clear cell adenocarcinoma of the urinary tract (utCCA) is a rare, Müllerian-type tumor typically arising in the urethra of female patients with poorly understood pathogenesis. Here, we report the clinical, pathologic, and molecular characte…

Natural killer (NK) cells are critical regulators of immune processes during early pregnancy, playing a key role in maintaining maternal-foetal immune tolerance and supporting successful implantation. In particular, uterine NK cells, a spec…

In clinical drug development, two fundamental questions must be addressed: what is the success rate of drugs in clinical trial; how does such rate change over time. Here, a dynamic strategy for calculating clinical trial success rate (ClinS…

This study investigates changes in regional homogeneity (ReHo) of the brain in patients with adenomyosis accompanied by dysmenorrhea (AMD) before and after uterine artery embolization (UAE) surgery. ReHo is a resting-state functional magnet…

Severe acute pancreatitis (SAP) is a common abdominal emergency in clinical practice. Approximately 20%-40% of patients with SAP will be associated with acute lung injury (SAP-ALI), which is a major cause of death. Emodin (EMO) is a natural…

Endometrium plays a crucial role in embryonic growth and development. Endometrial-related diseases, such as endometritis, endometriosis, endometrial cancer, and intrauterine adhesions, hurt fertility and women's health. At present, these di…

BACKGROUND: Adenomyosis is a prevalent gynecological condition among women of reproductive age and is commonly associated with heavy menstrual bleeding, severe dysmenorrhea, and infertility. These symptoms impose a substantial burden on bot…

Background: the distribution of human papillomavirus (HPV) infection, vaccination rates, and awareness levels varies across China. Methods: this study examined HPV infection prevalence, vaccine uptake, and barriers among 2440 women aged 30-…

Uterine scarring is a common complication following uterine injury, characterized by abnormal wound healing in the endometrial or myometrial tissue. However, the underlying mechanisms contributing to scar formation remain unclear, impeding …

Endometriosis (EM) is a chronic, estrogen-dependent disease characterized by the ectopic presence of endometrial-like tissue. Despite extensive research, its molecular pathogenesis remains unclear. In this study, we conducted an integrated …

BACKGROUND: Bisphenol A (BPA), a widespread environmental endocrine disruptor, has raised concerns for its neurotoxic effects, yet its molecular role in stroke remains unclear. METHODS: BPA target genes were retrieved from ChEMBL, DrugBank,…

Renal cell carcinoma (RCC) is the most lethal malignancy of the urinary system, with limited treatment options due to drug resistance and the adverse effects associated with current therapies. This review aims to systematically examine the …

This review explores the non-invasive applications of Raman spectroscopy in assisted reproductive technology (ART). Raman spectroscopy, a powerful tool for analyzing biological samples, has shown great potential in enhancing ART outcomes th…

IntroductionThe aim of the study was to explore the impact of the clinical and embryological factors on the pregnancy outcome of FET cycle, while determining the applicability range for the primary predictor.MethodsA total of 4395 FET cycle…

This study investigates the role of paraneoplastic Ma antigen 5 (PNMA 5), a member of the PNMA family of proteins, in ovarian endometriosis (EM). These proteins are known to play a significant role in various physiological activities and ar…

BACKGROUND: Latent Mycobacterium tuberculosis infection (LTBI) is common among patients with infertility, yet its effects on ovarian reserve function and pregnancy outcomes in women undergoing assisted reproductive technology (ART) remain u…

Endometriosis, the most prevalent cause of infertility, is associated with anatomical distortion leading to adhesions and fibrosis, as well as endocrine abnormalities and immune disorders. This review discusses the mechanisms underlying end…

AIMS: Endometriosis development is associated with peritoneal immune microenvironment abnormality; however, the specific mechanism is uncertain. We aimed to investigate the effects and underlying mechanisms of uterine cavity-derived exosome…

BackgroundTo validate previous age subgrouping methods and provide an optimal age reference for women planning to delay in vitro fertilization (IVF).MethodsFrom July 2014 to March 2018, 3012 patients that received IVF/intracytoplasmic sperm…

Objective: Immune-metabolic interactions may have causal and therapeutic impacts on abdominal aortic aneurysms (AAAs). However, due to the lack of research on the relationship between immune-metabolic interactions and AAAs, further explorat…

Qing Zhang,1,2,* Xiaowen Liang,1,2,* Zhiyi Chen1– 3 1Key Laboratory of Medical Imaging Precision Theranostics and Radiation Protection, College of Hunan Province, the Affiliated Changsha Central Hospital, Hengyang Medical School, University…

BACKGROUND: An increasing body of observational studies have indicated an association between gut microbiota and endometriosis. However, the causal relationship between them is not yet clear. In this study, we employed Mendelian randomizati…

Early pregnancy loss (EPL) is a common event in human reproduction and is classified into histological subtypes such as hydropic abortion (HA) and hydatidiform moles, including complete hydatidiform moles (CHMs) and partial hydatidiform mol…