Aaron S Meyer

No ORCID on file · 2 papers in corpus · active 2013-2015

Study types

  • article 2

Condition tags

  • endometriosis 2
article 2015
Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain
Scientific reports ·doi:10.1038/srep15150

Dysregulation of ErbB-family signaling underlies numerous pathologies and has been therapeutically targeted through inhibiting ErbB-receptors themselves or their cognate ligands. For the latter, "decoy" antibodies have been developed to seq…

article 2013
ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1222387110

A Disintegrin and Metalloproteinases (ADAMs) are the principal enzymes for shedding receptor tyrosine kinase (RTK) ectodomains and ligands from the cell surface. Multiple layers of activity regulation, feedback, and catalytic promiscuity im…