Pierre J. Courtoy

No ORCID on file · 20 papers in corpus · active 1995-2015

Study types

  • article 18
  • other 1
  • review 1

Condition tags

  • mesh:D004715 3
  • endometriosis 3
other 2015
Induction of post-menstrual regeneration by ovarian steroid withdrawal in the functionalis of xenografted human endometrium
Human Reproduction ·doi:10.1093/humrep/dev043

STUDY QUESTION: Does the endometrial functionalis have the potential to undergo self-renewal after menstruation and how is this process controlled by ovarian steroids? SUMMARY ANSWER: Endometrial xenografts subjected to withdrawal of estra…

article 2014
Matrix metalloproteinase-27, an intracellular protease expressed by M2 macrophages in human endometrium and endometriosis
article 2014
Matrix metalloproteinase-27 is expressed in CD163+/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions
Molecular human reproduction ·doi:10.1093/molehr/gau034

Matrix metalloproteinases (MMPs) are key enzymes involved in extracellular matrix remodelling. In the human endometrium, the expression and activity of several MMPs are maximal during the menstrual phase. Moreover, MMPs are thought to be in…

article 2013
Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation
·doi:10.1096/fj.13-232074

Menstrual endometrial breakdown induced by estradiol and progesterone withdrawal is regularly attributed to vasospasm of spiral arteries causing ischemia and hypoxia. We investigated whether hypoxia actually occurred in an in vivo model of …

article 2010
Matrix Metalloproteinase-27 is expressed in CD163+/CD206+ macrophages in the human endometrium and in endometriotic lesions
article 2009
Matrix Metalloproteinase-27 Is Expressed in Eutopic Endometrium and in Endometriotic Lesions
article 2009
Spatiotemporal Coupling of Focal Extracellular Matrix Degradation and Reconstruction in the Menstrual Human Endometrium
·doi:10.1210/en.2009-0750

Coupling of focal degradation and renewal of the functional layer of menstrual endometrium is a key event of the female reproductive biology. The precise mechanisms by which the various endometrial cell populations control extracellular mat…

article 2008
Menstrual activity of matrix metalloproteinases is decreased in endometrium regenerating after thermal ablation
·doi:10.1093/humrep/den392

BACKGROUND: Menstruation is associated with a striking increase in matrix metalloproteinase (MMP) activity. However, it is still unknown whether the level of MMP activity correlates with the amount of menstrual bleeding. METHODS: We used hi…

article 2007
Differential regulation of Transforming Growth Factor-beta mRNA expression in the human endometrium : contribution of the MAP-kinases pathways
article 2005
Regulation of Matrix Metalloproteinase-9/Gelatinase B Expression and Activation by Ovarian Steroids and LEFTY-A/Endometrial Bleeding-Associated Factor in the Human Endometrium
·doi:10.1210/jc.2004-1277

Various matrix metalloproteinases (MMPs) participate in the menstrual breakdown of the human endometrium. MMP-9/gelatinase B is proposed as a major factor because it degrades many extracellular matrix constituents, including in the vasculat…

article 2004
Evidence that irregular dysfunctional endometrial bleeding is due to focal expression and activity of matrix metalloproteinases.
article 2004
Focal Expression and Final Activity of Matrix Metalloproteinases May Explain Irregular Dysfunctional Endometrial Bleeding
·doi:10.1016/s0002-9440(10)63277-4
review 2002
Circulating Ovarian Steroids and Endometrial Matrix Metalloproteinases (MMPs)
·doi:10.1111/j.1749-6632.2002.tb02773.x

Recent studies strongly suggest that matrix metalloproteinases (MMPs) play a key role in the initiation of menstrual bleeding in the human endometrium upon the fall of ovarian steroid serum concentrations by inducing the degradation of the …

article 2000
The matrix metalloproteinase-1 (MMP-1) expression in the human endometrium is inversely regulated by interleukin-1 alpha and sex steroids.

OBJECTIVE: To investigate the regulation of perimenstrual MMP-1 expression in human endometrium. DESIGN: In vitro study utilizing epithelial-stromal co-cultures. SETTING: Cell Biology Unit, International Institute of Cellular and Molecular …

article 1999
Local cytokines induce differential expression of matrix metalloproteinases but not their tissue inhibitors in human endometrial fibroblasts
·doi:10.1046/j.1432-1327.1999.00001.x

The endometrium is the only human tissue to undergo cyclic breakdown and regeneration. This physiological alternation renders it an advantageous system for studying tissue remodelling. Our previous observations indicate that menstrual endom…

article 1997
Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions
Fertility and Sterility ·doi:10.1016/s0015-0282(97)81510-5
article 1996
Focal cellular origin and regulation of interstitial collagenase (matrix metalloproteinase-1) are related to menstrual breakdown in the human endometrium
·doi:10.1242/jcs.109.8.2151

Recent studies suggest that interstitial collagenase (MMP-1) is an essential enzyme in the early events leading to menstruation. This study analyses its cellular origin, regulation and relation to extracellular matrix breakdown in the human…

article 1996
Regulation and restricted expression of interstitial collagenase suggest a pivotal role in the initiation of menstruation
·doi:10.1093/humrep/11.suppl_2.134

Collagenases are the only mammalian enzymes able to cleave, at neutral pH, the triple helical domain of fibrillar collagens, major constituents of the extracellular matrix of the endometrium. Interstitial collagenase is expressed, secreted …

article 1995
[Collagenase and Related Matrix Metalloproteinases - a Prominent Role in the Initiation of Menstruation]

The human endometrium shows striking structural changes during the menstrual cycle. If no pregnancy develops, the fall of plasma progesterone and estradiol induces extracellular matrix degradation leading to haemorrhagia and mucosal sheddin…

article 1995
The expression of interstitial collagenase in human endometrium is controlled by progesterone and by oestradiol and is related to menstruation
·doi:10.1042/bj3051027

Human endometrial tissue, sampled at different periods of the reproductive cycle, expressed interstitial collagenase mRNA, protein and activity only just before and during the menstrual period. This clear-cut correlation and the inhibition …