OBJECTIVES: To investigate whether the CaMKKβ/AMPK/HIF-1α signaling pathway participates in angiogenesis in endometriosis by regulating mitophagy. METHODS: Human endometrial stromal cells (hEM15A) isolated from endometriosis patients and n…
Elagolix sodium (ELS), a non-peptide oral gonadotropin-releasing hormone receptor (GnRH) antagonist approved for the treatment of endometriosis-associated pain, displays atypical gelation in aqueous environments along with challenging physi…
Objective To investigate the potential molecular mechanism of Jiawei Shaofu Zhuyutang (JWSFZYT) in the treatment of endometriosis through regulating platelet activation via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/gly…
Objective To investigate the potential molecular mechanism of Jiawei Shaofu Zhuyutang (JWSFZYT) in the treatment of endometriosis through regulating platelet activation via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/gly…
Endometriosis (EMs) is a common and refractory disease in clinical practice.It has the pathological characteristics of adhesion and invasion,while the pathogenesis remains unclear.In recent years,studies have found that autophagy and ferrop…
BACKGROUND: To identify autophagy- and immune-related hub genes affecting the diagnosis and treatment of endometriosis. METHODS: Gene expression data were downloaded from the Gene Expression Omnibus (GEO) (GSE11691 and GSE120103 for traini…
This study aims to decipher the mechanism underlying the effect of Shaofu Zhuyu Decoction on endometriosis(EMT)-associated dysmenorrhea in rats with the syndrome of cold coagulation and blood stasis based on mitogen-and stress-activated pro…
BACKGROUND: The abnormality of endometrial stromal cells (ESCs) can contribute to endometriosis pathogenesis. Circular RNAs (circRNAs) possess critical roles in endometriosis pathogenesis. Here, we defined the activity and mechanism of huma…
A rapid response is necessary to contain emergent biological outbreaks before they can become pandemics. The novel coronavirus (SARS-CoV-2) that causes COVID-19 was first reported in December of 2019 in Wuhan, China and reached most corners…
Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP) and Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine(BATMAN-TCM) were searched for the effective components and targ…