Research Progress of Autophagy and Ferroptosis in Endometriosis

Yuan-Huan Chen, Chen YH, Cui Zhao, Zhao C, Wu QS, Quan-Sheng Wu, Mao HY, Hai-Yan Mao, Bin Yue, Yue B, Xiao-Hua Zhang, Zhang XH
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae · 2026 · vol. 48(4) , pp. 701–710 · doi:10.3881/j.issn.1000-503X.16928 · PMID:42660839
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⚙ AI-generated summary by qwen3.7-flash, 2026-09-04 ⓘ

This review examines the mechanisms of autophagy and ferroptosis in endometriosis, highlighting their molecular crosstalk to elucidate disease pathogenesis and identify potential therapeutic targets for ectopic lesion progression.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-04 · read from full text ⓘ

This review article examines the molecular mechanisms linking autophagy and ferroptosis to the pathogenesis of endometriosis. It details how dysregulation in these cell death pathways contributes to the survival and proliferation of ectopic endometrial cells, thereby promoting disease progression. The authors synthesize current literature to highlight potential therapeutic targets that modulate these processes for clinical intervention. This paper is centrally about endometriosis — specifically exploring the roles of autophagy and ferroptosis in its underlying pathology.

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Abstract

Endometriosis （EMs） is a common and refractory disease in clinical practice.It has the pathological characteristics of adhesion and invasion，while the pathogenesis remains unclear.In recent years，studies have found that autophagy and ferroptosis are two important regulatory mechanisms of cell life activities，closely related to cell survival and death，and they play a key role in EMs.Moreover，the two have crosstalk cooperation at the molecular level.Whether this interplay contributes to the pathogenesis occurrence and progression of EMs warrants further investigation.Therefore，conducting targeted experiments in vitro and in vivo to clarify the mechanisms of autophagy，ferroptosis，and their interaction in the occurrence and progression of EMs can not only delve into the invasion and migration processes of ectopic lesions in the pelvis and abdomen but also provide new ideas and targets for the treatment of EMs.This article reviews the mechanisms of autophagy and ferroptosis in EMs and the key targets of autophagy-dependent ferroptosis，aiming to provide new strategies and a theoretical basis for revealing the etiology and pathogenesis and developing new prevention and treatment options of EMs.
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MeSH descriptors

Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Autophagy Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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