D Hapangama

No ORCID on file · 10 papers in corpus · active 2010-2026

Study types

  • article 9
  • review 1

Condition tags

  • endometriosis 5
  • dysmenorrhea 1
  • infertility 1
  • dyspareunia 1
article 2026
L26/O-080 Predictors of satisfaction regarding hormonal therapy use in women with endometriosis and/or adenomyosis: Dutch results from the international TEPEA-study
·doi:10.1093/humrep/deag083.080

Abstract Study question Which clinical, treatment-related and informational factors are associated with satisfaction with hormonal therapies (HTs) in women with endometriosis and/or adenomyosis? Summary answer Satisfaction with HT was low, …

article 2026
L26/O-103 Complex in vitro 3D modelling of endometriosis and endometrial disorders
·doi:10.1093/humrep/deag083.103

Abstract Endometriosis is a common and chronic condition causing pelvic pain and subfertility. Despite its prevalence, the pathophysiology of endometriosis remains poorly understood, due in part to disease complexity (superficial, ovarian a…

article 2026
L26/O-328 Spatial transcriptomic insights between eutopic endometrium, ectopic endometriosis and adenomyosis lesions
·doi:10.1093/humrep/deag083.326

Abstract Study question What spatially resolved transcriptional differences distinguish matched eutopic endometrium, ectopic endometriosis and adenomyosis lesions with comparison to control endometrium? Summary answer Compartment and layer-…

article 2026
L26/P-324 Investigating the effect of oxytocin on the inner and outer layers of the pregnant and non-pregnant human myometrium
·doi:10.1093/humrep/deag083.660

Abstract Study question Do uterotonics have different effects on the inner (IM) and outer (OM) layers of the human pregnant and non-pregnant myometrium? Summary answer Oxytocin dose-dependently augments contractions in the IM and OM of the …

article 2021
UP-REGULATION OF INTERLEUKINS AND THEIR UNDERLYING PART TO DEVELOP ENDOMETRIOSIS IN WOMEN EXPERIENCING RETROGRADE MENSTRUATION
·doi:10.31032/ijbpas/2021/10.2.5390a

Endometriosis is associated with dyspareunia, dysmenorrhea and often severe pelvic pain as well as considered a chronic inflammatory disease, defined by the presence of endometrial tissue outside the uterine cavity. An important general con…

article 2018
Does human endometrial LGR5 gene expression suggest the existence of another hormonally regulated epithelial stem cell niche?
·doi:10.1093/humrep/dey083

STUDY QUESTION: Is human endometrial leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) gene expression limited to the postulated epithelial stem cell niche, stratum basalis glands, and is it hormonally regulated? SUMMARY AN…

review 2016
Implications of telomeres and telomerase in endometrial pathology
Human reproduction update ·doi:10.1093/humupd/dmw044

BACKGROUND: Eukaryotic chromosomal ends are linear and are protected by nucleoprotein complexes known as telomeres. The complex structural anatomy and the diverse functions of telomeres as well as the unique reverse transcriptase enzyme, te…

article 2015
Human endometrial epithelial telomerase is important for epithelial proliferation and glandular formation with potential implications in endometriosis
Human Reproduction ·doi:10.1093/humrep/dev267

STUDY QUESTION: How does regulation of telomerase activity (TA) in human endometrial epithelial cells (EEC) by ovarian hormones impact on telomere lengths (TL) and cell proliferation? SUMMARY ANSWER: Healthy endometrial epithelial cell prol…

article 2011
Aberrant expression of metastasis-inducing proteins in ectopic and matched eutopic endometrium of women with endometriosis: implications for the pathogenesis of endometriosis
Human Reproduction ·doi:10.1093/humrep/der412

BACKGROUND: Endometriosis is a metastatic disease without obvious tumorigenesis. Expression of S100P, S100A4, osteopontin (OPN) or anterior gradient homologue 2 (AGR2) proteins can induce metastasis but fail to induce tumorigenesis per se. …

article 2010
Aberrant expression of regulators of cell-fate found in eutopic endometrium is found in matched ectopic endometrium among women and in a baboon model of endometriosis
Human Reproduction ·doi:10.1093/humrep/deq248

BACKGROUND: We have recently shown that women with endometriosis express an increased amount of telomerase and nucleolin, with concomitant loss of γ-H2AX in eutopic endometrium. To further examine these selected factors that regulate cell f…