D Hapangama

No ORCID on file · 6 papers in corpus · active 2010-2021

Study types

  • article 5
  • review 1

Condition tags

  • endometriosis 5
  • dysmenorrhea 1
  • infertility 1
  • dyspareunia 1
article 2021
UP-REGULATION OF INTERLEUKINS AND THEIR UNDERLYING PART TO DEVELOP ENDOMETRIOSIS IN WOMEN EXPERIENCING RETROGRADE MENSTRUATION
·doi:10.31032/ijbpas/2021/10.2.5390a

Endometriosis is associated with dyspareunia, dysmenorrhea and often severe pelvic pain as well as considered a chronic inflammatory disease, defined by the presence of endometrial tissue outside the uterine cavity. An important general con…

article 2018
Does human endometrial LGR5 gene expression suggest the existence of another hormonally regulated epithelial stem cell niche?
·doi:10.1093/humrep/dey083

STUDY QUESTION: Is human endometrial leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) gene expression limited to the postulated epithelial stem cell niche, stratum basalis glands, and is it hormonally regulated? SUMMARY AN…

review 2016
Implications of telomeres and telomerase in endometrial pathology
Human reproduction update ·doi:10.1093/humupd/dmw044

BACKGROUND: Eukaryotic chromosomal ends are linear and are protected by nucleoprotein complexes known as telomeres. The complex structural anatomy and the diverse functions of telomeres as well as the unique reverse transcriptase enzyme, te…

article 2015
Human endometrial epithelial telomerase is important for epithelial proliferation and glandular formation with potential implications in endometriosis
Human Reproduction ·doi:10.1093/humrep/dev267

STUDY QUESTION: How does regulation of telomerase activity (TA) in human endometrial epithelial cells (EEC) by ovarian hormones impact on telomere lengths (TL) and cell proliferation? SUMMARY ANSWER: Healthy endometrial epithelial cell prol…

article 2011
Aberrant expression of metastasis-inducing proteins in ectopic and matched eutopic endometrium of women with endometriosis: implications for the pathogenesis of endometriosis
Human Reproduction ·doi:10.1093/humrep/der412

BACKGROUND: Endometriosis is a metastatic disease without obvious tumorigenesis. Expression of S100P, S100A4, osteopontin (OPN) or anterior gradient homologue 2 (AGR2) proteins can induce metastasis but fail to induce tumorigenesis per se. …

article 2010
Aberrant expression of regulators of cell-fate found in eutopic endometrium is found in matched ectopic endometrium among women and in a baboon model of endometriosis
Human Reproduction ·doi:10.1093/humrep/deq248

BACKGROUND: We have recently shown that women with endometriosis express an increased amount of telomerase and nucleolin, with concomitant loss of γ-H2AX in eutopic endometrium. To further examine these selected factors that regulate cell f…