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Accurate pre-operative discrimination between ovarian endometriomas (EMs) and other benign ovarian tumors is crucial for surgical planning and fertility counseling. This study aimed to evaluate the diagnostic performance of serum CA125, CA1…

BACKGROUND: Ovarian endometriotic cysts represent a prevalent form of endometriosis and are typically identifiable via imaging modalities. Nonetheless, differentiating endometriotic cysts from other benign non-endometriotic ovarian cysts, s…

PURPOSE: To systematically evaluate and compare the quality, readability, and query-model consistency of adenomyosis-related content generated by two large language models, ChatGPT (GPT-5) and DeepSeek (R1). MATERIALS AND METHODS: In total…

PurposeThis study aimed to conduct a comprehensive bibliometric analysis to characterize global research patterns, scientific output, and emerging trends in the treatment of female chronic pelvic pain (CPP).MethodsPublications related to fe…

AIM: To summarize current evidence on the molecular mechanisms by which the cervicovaginal microbiota mediates post-injury endometrial repair and to discuss relevant microbiota-targeted intervention strategies. METHODS: A narrative review …

Globally, approximately 80-95% of women of reproductive age are affected by premenstrual syndrome and menstrual-related symptoms, which significantly impair their quality of life. Although non-steroidal anti-inflammatory drugs and hormonal …

Endometriosis-associated ovarian cancer (EAOC) is a rare subtype of ovarian cancer arising from the malignant transformation of endometriosis (EMS). Despite growing clinical awareness, its underlying pathogenic mechanisms are not fully unde…

Ascites, a hallmark of advanced ovarian cancer, severely impairs patient quality of life and contributes to therapeutic resistance. Current management strategies remain primarily palliative, highlighting the urgent need to elucidate the und…

Background and Objective: The ultrasound sliding sign dynamically assesses pouch of Douglas (POD) obliteration in suspected endometriosis. Transvaginal (TVS) and transrectal (TRS) ultrasound are used in patients with and without a self-repo…

Infertility remains a global challenge, with female factors accounting for the majority of cases. Endometrial receptivity (ER), the ability of the endometrium to accept and support embryo implantation, is a critical determinant of successfu…

BACKGROUND: Müllerian adenosarcoma (MA) is a rare low-grade malignant tumor. It is characterized by benign glandular epithelium and malignant sarcomatous stromal components. This tumor commonly arises in the uterine corpus. Primary ovarian …

BACKGROUND: Ischemic heart disease (IHD) may share biological mechanisms with cancer, including ovarian cancer, through pathways such as chronic inflammation and oxidative stress. However, the relationship between IHD and ovarian cancer sub…

IntroductionOvarian clear cell carcinoma (OCCC) accounts for about 5% of all epithelial ovarian cancers. Currently, its treatment mainly refers to high-grade serous carci-noma (HGSC). This study aimed to explore differences in clinical char…

AIMS: The present study aimed to examine the roles of circRNA-circSMAD2 and its regulatory mechanisms in endometriosis (EMs). BACKGROUND: Evidence has confirmed that circRNAs play multiple roles in regulating the occurrence and development…

PURPOSE: For unexpected low-prognosis patients (Group 1 and Group 2) defined by POSEIDON criteria, how to maximize the live birth rate while controlling the multiple birth rate by tailoring the embryo transfer number and quality? METHODS: …

Abstract Background The pathogenesis of adenomyosis remains incompletely understood, and no well-established biomarkers related to its inflammatory mediators have been identified. Aim This retrospective study aimed to investigate the assoc…

Gynecologic disorders, such as cervical and ovarian tumors, uterine fibroids, and endometriosis, present significant clinical challenges due to frequent recurrence, emerging chemoresistance, and undesirable effects associated with prolonged…

OBJECTIVE: To investigate the associations between oxidative DNA damage biomarkers (levels of 8-hydroxy-2'-deoxyguanosine [8-OHdG], telomere length [TL], human telomerase reverse transcriptase [hTERT], telomerase activity [TA] and polymorph…

Evidence suggest that dietary advanced glycation end products (AGEs) might exert harmful effects on female reproductive function. However, population-based studies exploring the associations between dietary AGEs intake and female infertilit…

OBJECTIVE: To investigate the causal effect of immune cells on endometriosis (EMS), we performed a Mendelian randomization analysis. METHODS: Mendelian randomization (MR) uses genetic variants as instrumental variables to investigate the c…

In the last decade, organoid research has entered a golden era, signifying a pivotal shift in the biomedical landscape. The year 2023 marked a milestone with the publication of thousands of papers in this arena, reflecting exponential growt…

Abstract Objectives To inform dysmenorrhea for exploring the possible pathogenesis of adenomyosis based on MRI classification criteria and serum CA125. Methods Patients before focused ultrasound ablation surgery were categorized into …

As a chronic inflammatory bowel disease, the pathogenesis of ulcerative colitis (UC) has not been fully elucidated. N6-methyladenosine (m6A) modification, observed in various RNAs, is implicated in inflammatory bowel diseases. Methyltransfe…