Scott D. Mendelson

article 2010

Differential roles of serotonin receptor subtypes in the modulation of lordosis behaviour in the female rat

·doi:10.14288/1.0098144

In 1985, Mendelson and Gorzalka proposed the dual role hypothesis of serotonergic modulation of lordosis behaviour. In this hypothesis it was proposed that serotonergic activity can either inhibit or facilitate lordosis behaviour. Specifica…

article 1990

Sex differences in the effects of 1-(m-trifluoromethylphenyl) piperazine and 1-(m-chlorophenyl) piperazine on copulatory behavior in the rat

·doi:10.1016/0028-3908(90)90133-c

Peripheral administrations of TFMPP (0.2- 1 mg/kg) or MCPP (1 mg/kg) facilitated lordosis behavior in female rats treated with estradiol benzoate, and had no effects in females primed with estradiol benzoate and progesterone. In contrast, T…

article 1988

Stimulation of β-adrenoceptors inhibits lordosis behavior in the female rat

·doi:10.1016/0091-3057(88)90193-1

Existing reports on the effects of beta-adrenergic antagonists on lordosis behavior appear contradictory, with (+/-) propranolol being reported to inhibit, and (+/-) pindolol to facilitate this behavior. In the present study, both the (-) a…

article 1987

Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat

·doi:10.1016/0014-2999(87)90086-0

Intraventricular administration of the tryptophan metabolites l-kynurenine (2-32 micrograms) and kynuramine (0.064-8 micrograms) facilitated lordosis behavior in estrogen-primed ovariectomized rats. The facilitatory effects of these drugs w…

article 1986

Effects of 5-HT1A selective anxiolytics on lordosis behavior: interactions with progesterone

·doi:10.1016/0014-2999(86)90625-4

Ipsapirone and gepirone, but not buspirone, facilitated lordosis in estrogen-treated rats, whereas all three drugs inhibited this behavior in rats treated with estrogen and progesterone. When administered at higher doses, ipsapirone, gepiro…

article 1986

Serotonin type 2 antagonists inhibit lordosis behavior in the female rat: Reversal with quipazine

·doi:10.1016/0024-3205(86)90272-9

The theory that activation of serotonin type 2 (5-HT2) receptors facilitates lordosis behavior in the female rat was tested. The 5-HT2 antagonists pizotefin, cyproheptadine, metitepine, and ketanserin were found to inhibit lordosis behavior…