OBJECTIVE: To evaluate Cox-2 inhibition on surgically induced endometriosis in rats. DESIGN: Prospective, randomized study SETTING: Academic facility. ANIMAL(S): Seventy adult female Sprague-Dawley rats. INTERVENTION(S): Uterine fragmen…
OBJECTIVE: To quantify the expression of transforming growth factor beta1 in nerve fibers in endometriotic lesions and to correlate it with dysmenorrhea and appearance of endometriotic implants. DESIGN: Prospective comparative study. SETT…
OBJECTIVE: To evaluate the degree of fibrosis in the stroma of peritoneal endometriosis, according to the macroscopic appearance. METHODS: Red and black lesions of peritoneal endometriosis were collected and type-I collagen was immunohisto…
We evaluated angiogenesis in eutopic endometrium and ectopic endometrium from patients with endometriosis. Microvessels were identified by immunohistochemistry using anti-von-Willebrand factor antibody and vascular parameters were measured …
PROBLEM: Factors regulating fibrosis in peritoneal endometriosis are poorly understood. We hypothesized that mast cell proteases may play a role in the process of fibrosis in peritoneal endometriosis. As the first step in examining the poss…