Mark D. Hornstein

BACKGROUND: Endometriosis is a prevalent but enigmatic gynecologic disorder for which few modifiable risk factors have been identified. Fish oil consumption has been associated with symptom improvement in studies of women with primary dysme…

ObjectiveTo compare patterns of luteal phase bleeding (LPB) in IVF cycles supplemented with Crinone and with intramuscular progesterone (IMP) and to evaluate the impact of luteal estrogen supplementation on LPB.DesignProspective, randomized…

the conclusion that women with a high fatty acid intake are less likely to undergo a laparoscopy since a high fatty acid intake can reduce menstrual pain. Finally, laparoscopy as a diagnostic tool will pick up also subtle endometriosis and …

BACKGROUND: In the one study examining the relationship, adolescent physical activity was not associated with risk for endometriosis. Case-control studies have shown 40-80% reductions in risk for adult activity, while only an 11% reduction …

BACKGROUND: Regular exercise has been associated with a 40%-80% reduction in risk for endometriosis in several case-control studies. However, women experiencing symptoms prior to their diagnosis may be less likely to exercise than healthy c…

Endometriosis affects 10-15% of women and is associated with pelvic pain and infertility. Angiogenesis plays an essential role in its pathogenesis. Dendritic cells (DCs) were recently implicated in supporting tumor angiogenesis. As both tum…

Endometriosis is defined as the presence of endometrial glands and stroma outside the uterine cavity. It is typically confined to the pelvis, particularly the ovaries, posterior cul-desac, anterior uterovesical peritoneum, uterosacral ligam…

ObjectiveTo investigate differences in characteristics of patients with endometriosis in the United States and the United Kingdom.DesignPatient questionnaire.SettingTwo university-based endometriosis referral centers.Patient(s)Women with su…

In Brief OBJECTIVE To assess post-treatment effects in endometriosis patients of a 12-month course of GnRH agonist alone or with one of three “add-back” regimens. METHODS This is a post-treatment follow-up analysis of a randomized, double-m…

OBJECTIVE: To assess post-treatment effects in endometriosis patients of a 12-month course of GnRH agonist alone or with one of three "add-back" regimens. METHODS: This is a post-treatment follow-up analysis of a randomized, double-masked, …

ObjectiveTo compare basal gonadotropin and estradiol levels between women using acetaminophen versus those using no or other types of analgesics.DesignObservational study.SettingThree IVF clinics in greater Boston.Patient(s)Three hundred ei…

PurposeThe effect of endometriomas on oocyte quality, embryo quality, and pregnancy rates in in vitro fertilization (IVF) cycles was evaluated.MethodsForty-five women had "chocolate" cysts aspirated at the time of oocyte retrieval, and cyst…

Hornstein, Mark D. MD; Surrey, Eric S. MD; Weisberg, Gerald W. MD; Casino, Leigh A. MT Author Information

OBJECTIVE: To evaluate the efficacy and safety of a GnRH agonist, leuprolide acetate depot, alone and in combination with three hormonal add-back regimens in the management of endometriosis-associated pelvic pain. METHODS: Two hundred and o…

ObjectiveTo assess the efficacy, safety, and effect on bone mineral density of a 3-month course of retreatment with intranasal nafarelin acetate for recurrent symptoms of endometriosis.DesignMulticenter, open-label, nonrandomized clinical t…

ObjectiveTo evaluate the efficacy of the GnRH agonist (GnRH-a) nafarelin compared with placebo administered for 6 months after reductive laparoscopic surgery for symptomatic endometriosis.DesignRandomized, prospective, placebo-controlled, m…

To explore a possible connection between endometriosis, Müllerian anomalies, and possession of the N314D allele of the gene for galactose-1-phosphate uridyl transferase (GALT), we studied 33 women with endometriosis attending a fertility cl…

Serum CA 125 concentrations are elevated in some women with endometriosis; however, the low sensitivity and specificity of the assay have made it impractical to use it as a diagnostic test for endometriosis. Recently a second-generation CA …

ObjectivesTo determine the effectiveness of a 3-month course of nafarelin and, furthermore, to determine the long-term efficacy in patients treated for 3 and 6 months with nafarelin for symptoms associated with endometriosis.DesignDouble-bl…

ObjectiveThe study intent was to examine long-term effects on bone mass of 3 or 6 months of nafarelin therapy for endometriosis.Study designWomen with established endometriosis (N = 173) were randomized to receive nafarelin (200 micrograms …

ObjectiveTo evaluate the safety and efficacy of leuprolide acetate depot (LA, Lupron; TAP Pharmaceuticals, Deerfield, IL) plus daily conjugated equine estrogens (Es, Premarin; Wyeth-Ayerst Laboratories, Philadelphia, PA), and medroxyprogest…