Prevalence of Small Intestinal Bacterial Overgrowth (SIBO) in Women With Endometriosis
NCT07922408
· ctgov
not_yet_recruiting
- Enrollment
- 50
- Start
- 2027-02-01
- Completion
- 2030-12-01
- Last updated
- 2026-11-06
- Has results
- False
- Countries
- Switzerland
Conditions
Tagged with
Interventions
-
Gastroduodenoscopy, luminal aspirate, mucosal biopsies, collection of mucus, lactulose breath test
DIAGNOSTIC_TEST
SIBO testing will be conducted at the clinic for gastroenterology, Bern using standardized diagnostic procedures, including the lactulose breath test, gastroduodenoscopy with collection of luminal aspirate, mucus and mucosal biopsies, and complementary stool analyses. The diagnostic gold standard for SIBO is the microbiological analysis of small intestinal luminal aspirate. SIBO is considered confirmed when bacterial concentrations exceeding 103. As an additional non-invasive diagnostic method, a hydrogen (H2) breath test using lactulose may be performed.
Eligibility criteria
Inclusion Criteria:
* Informed Consent as documented by signature
* Age 18 or older
* Premenopausal status (menopause is defined as amenorrhea lasting one year or longer)
* Diagnosis of endometriosis (Ziwig Endotest® or histologically confirmed)
Exclusion Criteria:
* Pregnant (positive β-HCG in the blood) or breastfeeding women Inability to follow the procedures of the study (due to language problems, psychological disorders, dementia)
* Presence of medical conditions contraindicating a saliva test
* Diagnosis of another gastrointestinal major diagnosis
* Presence of any condition known to associate with/ increase risk for SIBO (other than endometriosis) namely
1. Scleroderma, diabetic neuropathy, amyloidosis, post-vagotomy, morbid obesity , non-alcoholic fatty liver disease, liver cirrhosis, cystic fibrosis, irritable bowel syndrome, altered intestinal anatomy such as diverticula.
2. Patients with intake of medicaments known to inhibit motility or gastric acid secretion
3. Patients with choledocholithiasis or malignancy within the biliary tree or at the ampullary region obstructing biliary outflow
License: public-domain-us
· commercial use OK
· attribution required
Courtesy of ClinicalTrials.gov / U.S. National Library of Medicine
Courtesy of ClinicalTrials.gov / U.S. National Library of Medicine