The Use of Low Dose Metronidazole to Decrease Postoperative Pain After Endometriosis Surgery
NCT04554693
· ctgov
terminated
phase phase-4
- Enrollment
- 78
- Start
- 2020-10-19
- Completion
- 2023-10-05
- Last updated
- 2026-06-18
- Has results
- True
- Countries
- United States
Conditions
Tagged with
Interventions
-
Metronidazole Oral
DRUG
250 mg oral three times a day for 14 days
-
Placebo
DRUG
Halal and Kosher certified gelatin placebo capsules oral three times a day for 14 days
Eligibility criteria
Inclusion Criteria:
* Able to give informed consent
* Women aged 18-50 years old
* Scheduled to undergo excision of endometriosis
* Able to read and write in English and or Spanish
* Pain score \> 2 on a 10 point visual analogue scale at baseline
* Negative screening by CAGE questionnaire
Exclusion Criteria:
* Refusal to surgery
* Contraindication to surgery
* Known allergy to metronidazole
* Known allergy to any component in gelatin placebo capsules
* Scheduled hysterectomy
* Endometriosis excision surgery within the last 3 months
* Elevated serum creatinine
* Abnormal liver function test greater than 2 times the normal
* Current pregnancy
* Breastfeeding
* Use of Disulfiram within the last 2 weeks
* History of Cockayne syndrome
* Inability to abstain from alcohol during the use of study drug
License: public-domain-us
· commercial use OK
· attribution required
Courtesy of ClinicalTrials.gov / U.S. National Library of Medicine
Courtesy of ClinicalTrials.gov / U.S. National Library of Medicine