First Equine Herpes Mieloencephalopathy (EHM) outbreak in Chile

First Equine Herpes Mieloencephalopathy (EHM) outbreak in Chile | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 30 May 2025 V1 Latest version Share on First Equine Herpes Mieloencephalopathy (EHM) outbreak in Chile Authors : María Carolina Durán 0000-0003-2170-1626 , Macarena Suazo , Antonia Maturana , María Paz Vargas , Alfonso Garcia , Alexza Pezoa , Lutz Goehring 0000-0001-8493-0675 , and Felipe Andres Lara Hidalgo [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174861057.76792185/v1 143 views 78 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background : This is the first EHV-1 outbreak with EHM in Chile. Objectives : Describe clinical, epidemiological and outcome data from an EHM outbreak in South America. Study design : Case Report, retrospective outbreak data analysis. Methods : Clinical and diagnostic data were analyzed. EHV-1 was detected by qPCR (EHV-1-Glycoprotein-B). Frequency tables were used for descriptive analysis of categorical variables and the chi-square test and Cramer’s V to test relationships between them. Results : A total of 567 Polo Horses were kept in the Polo operation, 58.4% were mares and 41.6% geldings and stallions. Mean age was 9.7±0.132 years. 13 horses showed clinical signs compatible with EHV-1 infection, 8 had fever (1.4%) and 11 developed EHM (1.9%). Only 6/11 horses developed EHM and high fevers (>39.5C). The mortality rate was 0.35% (index case and case 1) while morbidity 3.35% (19/567 horses). PCR analysis was performed in 214 horses (37.7%), 201 were negative for EHV-1 (93.9%) and 13 positive (6.1%). 7 horses with a positive PCR presented clinical signs (53.8%), while 6 with a negative PCR result did show clinical signs compatible with EHV-1 infection (2.9%). CT values of positive PCR results ranged from 30 to 39. Main limitations : Limited number of horses were diagnostically analyzed (PCR and/or serology analysis). Viral isolation and sequencing have not yet been achieved. Conclusions : This is the first EHM outbreak reported in Chile showing low morbidity and mortality rates. Viral spread was successfully controlled with prompt and strict quarantine and biosecurity measures. More information on viral prevalence and type during the outbreak and in the Chilean horse population is required to further understand the outbreak and prepare for the impact of future ones. Supplementary Material File (main_manuscript_ehv-1_outbreak.docx) Download 5.05 MB Information & Authors Information Version history V1 Version 1 30 May 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations María Carolina Durán 0000-0003-2170-1626 Universidad Andres Bello Facultad de Ciencias de la Vida View all articles by this author Macarena Suazo Universidad Andres Bello Facultad de Ciencias de la Vida View all articles by this author Antonia Maturana Universidad Andres Bello Facultad de Ciencias de la Vida View all articles by this author María Paz Vargas no affiliation View all articles by this author Alfonso Garcia Servicio Agricola y Ganadero View all articles by this author Alexza Pezoa Servicio Agricola y Ganadero View all articles by this author Lutz Goehring 0000-0001-8493-0675 University of Kentucky Maxwell H Gluck Equine Research Center View all articles by this author Felipe Andres Lara Hidalgo [email protected] Universidad Andres Bello Facultad de Ciencias de la Vida View all articles by this author Metrics & Citations Metrics Article Usage 143 views 78 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation María Carolina Durán, Macarena Suazo, Antonia Maturana, et al. First Equine Herpes Mieloencephalopathy (EHM) outbreak in Chile. Authorea . 30 May 2025. DOI: https://doi.org/10.22541/au.174861057.76792185/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); Cited by Guangyi Liu, Xiaoyang Zhao, Yuezhi Lin, Xiaojun Wang, Diqiu Liu, A Comparative Review of Veterinary and Human Vaccine Development Strategies: Insights into Herpesvirus Vaccinology from Latency to Elimination, Vaccines, 14 , 3, (249), (2026). https://doi.org/10.3390/vaccines14030249 Crossref Muhammad Zahoor Khan, Yanfei Ji, Xuewei Fan, Yihong Liu, Wenqiang Liu, Changfa Wang, Equine Herpesvirus Infections: Treatment Progress and Challenges in Horses and Donkeys, Veterinary Sciences, 12 , 11, (1082), (2025). https://doi.org/10.3390/vetsci12111082 Crossref Loading... View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.174861057.76792185/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'9ffc51444c7f300f',t:'MTc3OTQ1ODExNQ=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();