Mathematical study for the phase-based transmissibility of a novel COVID-19 Coronavirus

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This paper mathematically models COVID-19 transmission using a SEIRW model and proves that the disease-free equilibrium is stable when the basic reproduction number is less than or equal to one, and the disease-persistence equilibrium is stable when it exceeds one.

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The paper studies a mathematical dynamical system using an SEIRW model to analyze phase-based transmissibility of a novel COVID-19 coronavirus. Using qualitative methods, it performs local and global stability analyses of equilibrium points, relying on a direct Lyapunov approach and LaSalle’s invariance principle. The authors prove that when the basic reproduction number satisfies R ≤ 1, the disease-free equilibrium is globally asymptotically stable, while for R > 1 the disease-persistence equilibrium is globally asymptotically stable. A key limitation stated is that the work is a preprint and has not been peer reviewed by a journal. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Abstract In this paper, a mathematical dynamical system modeling a SEIRW model of infectious disease transmission for a transmissibility of a novel COVID-19 Coronavirus is studied. A qualitative analysis such as the local and global stability of equilibrium points is carried out.It is proved that if $\R \leq 1$, then the disease-free equilibrium is globally asymptotically stable and if $\R > 1$, then the disease-persistence equilibrium is globally asymptotically stable.
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Mathematical study for the phase-based transmissibility of a novel COVID-19 Coronavirus | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Mathematical study for the phase-based transmissibility of a novel COVID-19 Coronavirus Miled EL HAJJI, Sayed SAYARI, Abdelhamid ZAGHDANI This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-26318/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract In this paper, a mathematical dynamical system modeling a SEIRW model of infectious disease transmission for a transmissibility of a novel COVID-19 Coronavirus is studied. A qualitative analysis such as the local and global stability of equilibrium points is carried out. It is proved that if $\R \leq 1$, then the disease-free equilibrium is globally asymptotically stable and if $\R > 1$, then the disease-persistence equilibrium is globally asymptotically stable. Infectious Diseases Mathematical and Theoretical Biology COVID-19 Coronavirus SEIRW Model Local and Global Stability Direct Lyapunov Method Lasalle's Invariance Principle Figures Figure 1 Figure 2 Figure 3 Full Text Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-26318","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":535246,"identity":"9844c0fe-6d10-4d19-91a7-44632c3f4bc0","order_by":1,"name":"Miled EL HAJJI","email":"","orcid":"https://orcid.org/0000-0002-4718-4463","institution":"ENIT-LAMSIN, BP. 37, 1002 Tunis-Belv\\'ed\\`ere, Tunis El Manar University, Tunisia \u0026 Higher Institute of Applied Science and Technology of Sousse, Sousse University, Cit\\'e Taffala, 4003 Sousse, Tunisia","correspondingAuthor":false,"prefix":"","firstName":"Miled","middleName":"EL","lastName":"HAJJI","suffix":""},{"id":535247,"identity":"04e31642-8616-4931-8e2c-19466bf330ca","order_by":2,"name":"Sayed SAYARI","email":"","orcid":"","institution":"Carthage University, Isteub, 2 Rue de l'Artisanat Charguia 2, 2035 Tunis, Tunisia","correspondingAuthor":false,"prefix":"","firstName":"Sayed","middleName":"","lastName":"SAYARI","suffix":""},{"id":535248,"identity":"47aa3160-9e16-456f-8dd4-274611b96be4","order_by":3,"name":"Abdelhamid ZAGHDANI","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABC0lEQVRIie3RsUrEMBjA8a8c1CVya4/iPUOOwolQFN8kH4VMdnLpWDjodHDriaKvEPEFvlLIYrFr4UTrfgcdndRW3KQttwnmD8kQ8iMJATCZ/mC8GcTAZzZkRCLyAZx23R8kcjq2NFZ1Ln+I7CfAIPMmi9ybXSXZMDk+eETaRiNUmuYuswtcXS/SCsRLJzlZhiq9yW1UOUmXsQ2un3XAQVx2X4xClR0mDFVJ2mXOBuPyYu5Y76KbFLuWOKhe3xKX8Se8awmIHlJ+n8K9SZyNZmtBzXGDZNe+RUzHoK2qpsC7L2XARR8pwod6G302X1nUhB+nR7dlkFZ1D/nVedzOewCAs302m0wm0//oCyHSaEu8a+DRAAAAAElFTkSuQmCC","orcid":"","institution":"University of Tunis, Boulevard du 9 Avril 1939 Tunis. 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