Особливості клінічного перебігу залізодефіцитної анемії у жінок 40-55 років

In: Ukrainian Journal of Military Medicine · 2021 · vol. 2(2) , pp. 49–60 · doi:10.46847/ujmm.2021.2(2)-049 · W3184365243
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This study identified heavy menstrual bleeding, gastrointestinal inflammation, low meat consumption, and anticoagulant use as primary causes of iron deficiency anemia in women aged 40-55.

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The paper reviews European evidence and analyzes clinical data from 109 women aged 40–55 years followed in a hematology clinic in Kyiv from 2015–2019, focusing on causes and risk factors for iron deficiency/iron deficiency anemia and their clinical course. It reports that the most common causes were heavy menstrual blood loss (21.1%), gastrointestinal inflammatory processes (19.26%), reduced meat intake (13.76%), and anticoagulant use (10.1%), with a multifactorial pattern dominating the observed etiologies. The study explicitly emphasizes that anemia in this age group represents a public health problem affecting efficiency and quality of life, while the analysis is limited by the use of clinic-based observations and reliance on summarized European studies for broader risk context. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Вступ. Дефіцит заліза (ДЗ) є серйозною проблемою у жінок віком 40-55 років. В цей період відбувається варіації гормональних рівнів, порушення менструального циклу з ризиком виникнення тяжкої крововтрати. Крім того, жінки цієї вікової групи часто ведуть нездоровий спосіб життя, з наступним розвитком порушень, що призводять до змін у фізичному і психічному станах. Мета роботи. Дослідити причини розвитку ЗДА у жінок, які знаходилися під спостереженням у клініці гематології Національного військового медичного клінічного центру «Головний військовий клінічний госпіталь» МО України і визначити фактори ризику розвитку анемії та її корекції. Матеріали та методи. У статті надані дані європейських досліджень про високий ризик розвитку дефіциту заліза/залізодефіцитної анемії (ДЗ/ЗДА) у жінок віком 40-55 років. Проведений аналіз обстеження та лікування 109 жінок, котрі знаходилися під спостереженням у клініці гематології Національного військово‐медичному клінічному центрі «ГВКГ» (м. Київ) з 2015 по 2019 роки. Результати. Узагальнено сучасні наукові європейські дослідження щодо ризику розвитку ДЗ/ЗДА у жінок віком 40-55 років. Проведено аналіз причин розвитку ЗД/ЗДА за результатами обстеження та лікування жінок, котрі знаходилися під спостереженням у клініці гематології Національного військово‐медичному клінічному центрі «ГВКГ» (м. Київ) з 2015 по 2019 роки. Виділено найбільш часті причини розвитку ЗД/ЗДА: рясні менструальні крововтрати, запальні процеси в органах шлунково-кишкового тракту, зниження вживання м'ясних продуктів, прийоми антикоагулянтів, порушення дієти з метою схуднення, що в цілому складає 75% серед можливих причин. Висновки. За даними європейських досліджень виявлено високий ризик розвитку ДЗ/ЗДА у жінок віком 40-55 років при цьому клінічні прояви ЗДА у жінок віком 40-55 років є проблемою суспільної охорони здоров’я, оскільки призводить не тільки до зниження працездатності, але й до зниження якості життя жінок. Результати проведених досліджень свідчать про багатофакторну структуру причин розвитку ДЗ у жінок віком 40-55 років, головними з яких є рясні менструальні крововтрати (21,1%), запальні процеси в органах шлунково-кишкового тракту (19,26%), зниження вживання м'ясних продуктів (13,76%), прийоми антикоагулянтів (10,1%). Показано, що визначення факторів ризику розвитку анемії і корекції цих негативних проявів за допомогою препаратів заліза є актуальним завданням для лікаря.
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Abstract

Introduction. Iron deficiency (ID) is a serious problem in women aged 40-55 years. During this period there are variations in hormonal levels, menstrual irregularities with the risk of severe blood loss. In addition, women in this age group often lead unhealthy lifestyles, followed by the development of disorders that lead to changes in physical and mental states. The purpose: to determine the causes of iron deficiency anemia in women who were under observation in the hematology clinic of the National Military Medical Clinical Center «Main Military Clinical Hospital» of the Ministry of Defense of Ukraine and identify risk factors for anemia and its correction.

Materials

and methods. The article presents data from European studies on the high risk of developing iron deficiency / iron deficiency anemia (IDA) in women aged 40-55 years. The analysis of examination and treatment of 109 women who were under observation in the hematology clinic of the National Military Medical Clinical Center «GVKG» (Kyiv) from 2015 to 2019. Results. Modern European scientific research on the risk of developing ІD / IDA in women aged 40-55 years is summarized. An analysis of the causes of IDA in women based on the results of examination and treatment of women who were under observation in the hematology clinic of the National Military Medical Clinical Center «GVKG» (Kyiv) from 2015 to 2019. The most common causes of ID / IDA are: heavy menstrual blood loss, inflammatory processes in the gastrointestinal tract, reduced consumption of meat products, anticoagulants, dietary disorders for weight loss, which is generally 75% of the possible causes. Conclusions. According to European studies, there is a high risk of developing ID / IDA in women aged 40-55 years, while the clinical manifestations of IDA in women aged 40-55 years is a public health problem, as it leads not only to reduced efficiency but also to reduced quality of women life. The results of the studies indicate a multifactorial structure of the causes of IDA in women aged 40-55 years, the main of which are abundant menstrual blood loss (21.1%), inflammatory processes in the gastrointestinal tract (19.26%), reduced use of meat products (13.76%), anticoagulants (10.1%). It is shown that determining the risk factors for the development of anemia and the correction of these negative manifestations with the help of iron supplements is an urgent task for the doctor.

References

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