Procedural Characteristics, Extent of Acute Antral Lesion Size, and Myocardial Injury with Two Different Pulsed Field Ablation Systems - The Dual Pulse System Study

Procedural Characteristics, Extent of Acute Antral Lesion Size, and Myocardial Injury with Two Different Pulsed Field Ablation Systems - The Dual Pulse System Study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 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Data may be preliminary. 11 March 2025 V1 Latest version Share on Procedural Characteristics, Extent of Acute Antral Lesion Size, and Myocardial Injury with Two Different Pulsed Field Ablation Systems - The Dual Pulse System Study Authors : Behnam Subin , Corinne Isenegger 0009-0001-9623-3997 , David Spreen , Philipp Krisai 0000-0002-4367-2363 , Sven Knecht 0000-0001-7122-021X , Gian Voellmin , Nicolas Schärli , Felix Mahfoud , Michael Kühne , Christian Sticherling , and Patrick Badertscher 0000-0001-9751-0557 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174172694.46774939/v1 Published European Heart Journal Version of record Peer review timeline 293 views 209 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: Recently, multiple pulsed field ablation (PFA)-system were introduced for catheter ablation (CA) of atrial fibrillation (AF). However, data comparing procedural performance, acute antral lesion size, and myocardial injury between different PFA-systems in a real-world setting remain scarce. Methods: Consecutive patients undergoing CA for AF were enrolled. PFA was performed using either a Pentaspline catheter-system (PCS) or a loop catheter-system (LCS). The extent of acute antral lesion size was assessed using a 3D-electroanatomical mapping system. High-sensitivity cardiac troponin T (hs-cTnT) was measured the day after the procedure to assess myocardial injury. Results: A total of 120 patients (median age 67 [59-73] years, 29% female) underwent de novo pulmonary vein isolation (PVI). The PCS-group included 90 patients, while the LCS-group included 30 patients. Acute PVI was achieved in all patients (100%). Procedural times were significantly shorter in the PCS compared to the LCS-group, including total procedure duration (57 [48-67] vs 66 [52–83] min, p=0.016), left atrial dwell time (38 [32–48] vs 54 [38–65] min, p<0.001), and ablation duration (17 [12–23] vs 24 [20–33] min, p<0.001). Acute antral lesion size and myocardial injury were significantly lower in the PCS compared to the LCS-group (6.6 [5.0–8.9] vs. 19.2 [16.8–25.4] cm 2 , p<0.001 and hs-cTnT of 1282 [892-1894] vs 1588 [1281-2110] ng/L, p=0.029. Conclusion: Significant differences were observed between two commercially available PFA-systems. While PCS was associated with significantly shorter procedural time, LCS resulted in a greater extent of acute antral lesion size and myocardial injury levels. Supplementary Material File (dual pulse system study.docx) Download 5.41 MB Information & Authors Information Version history V1 Version 1 11 March 2025 Peer review timeline Published European Heart Journal Version of Record 5 Nov 2025 Published Copyright This work is licensed under a Non Exclusive No Reuse License. Collection Journal of Cardiovascular Electrophysiology Keywords clinical: cardiac anatomy clinical: cardiac mapping – 3-dimensional systems clinical: catheter ablation – atrial fibrillation clinical: catheter ablation – non-rf energy sources clinical: electrophysiology – atrial arrhythmias Authors Affiliations Behnam Subin Universitatsspital Basel Kardiologie View all articles by this author Corinne Isenegger 0009-0001-9623-3997 Universitatsspital Basel Kardiologie View all articles by this author David Spreen Universitatsspital Basel Kardiologie View all articles by this author Philipp Krisai 0000-0002-4367-2363 Universitatsspital Basel Kardiologie View all articles by this author Sven Knecht 0000-0001-7122-021X Universitatsspital Basel Kardiologie View all articles by this author Gian Voellmin Universitatsspital Basel Kardiologie View all articles by this author Nicolas Schärli Universitatsspital Basel Kardiologie View all articles by this author Felix Mahfoud Universitatsspital Basel Kardiologie View all articles by this author Michael Kühne Universitatsspital Basel Kardiologie View all articles by this author Christian Sticherling Universitatsspital Basel Kardiologie View all articles by this author Patrick Badertscher 0000-0001-9751-0557 [email protected] Universitatsspital Basel Kardiologie View all articles by this author Metrics & Citations Metrics Article Usage 293 views 209 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Behnam Subin, Corinne Isenegger, David Spreen, et al. Procedural Characteristics, Extent of Acute Antral Lesion Size, and Myocardial Injury with Two Different Pulsed Field Ablation Systems - The Dual Pulse System Study. Authorea . 11 March 2025. DOI: https://doi.org/10.22541/au.174172694.46774939/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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