Endometriosis – the new approach and homoeopathic therapeutics

Tridibesh Tripathy, Anjali Tripathy, Sanskriti Tripathy
In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2026 · vol. 15(10) , pp. 4231–4235 · doi:10.18203/2320-1770.ijrcog20263480 · W7214621565
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This article reviews endometriosis through a mitochondrial lens to address pain and inflammation, advocating for holistic AYUSH therapies as preventive, cost-effective alternatives to traditional hormonal and surgical interventions.

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This article examines endometriosis through a mitochondrial lens, arguing that the condition involves cellular and metabolic dysfunction beyond traditional hormonal mechanisms. The authors propose that understanding pain, inflammation, and energy deficits requires integrating this new perspective into reproductive health missions and clinical strategies. They advocate for holistic interventions from the AYUSH system as preventive, cost-effective alternatives to current surgical or hormonal treatments. This paper is centrally about endometriosis, specifically proposing a mitochondrial framework for its pathogenesis and suggesting homoeopathic therapies as part of a broader management strategy.

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Abstract

An integral part of public health and especially the reproductive health since decades is the condition of endometriosis. The reproductive and child health (RCH) is a large chunk of the entire national health mission (NHM) where primarily the target is maternal and child health (MCH). As part of MCH and RCH, this article discusses the issue of endometriosis in the domain of reproductive life of a woman. It traverses through the fact that endometriosis in reproductive health is not only under the umbrella of hormonal domain but also it is a part of the cellular and metabolic functions in the body. The term cellular is aimed at the power house of the cell located in the cytoplasm, the mitochondria. The mitochondrial lens will help the medical fraternity to see the clinical condition of endometriosis in the perspective of new and emerging research. Simultaneously, it will help in comprehending the issues of pain, inflammation and cellular energy in endometriosis. With the new approach, missions, programs, strategies, objectives, activities and policies will have to be tuned with the issue of endometriosis. A holistic approach is the need of the hour amidst the current approaches that were primarily hormonal and surgical. Medical and clinicians need to adopt a therapeutic that is preventive, resilient, cost effective, clinical effective and has no side effects. Homoeopathy of ayurveda, yoga and naturopathy, unani, siddha, and homoeopathy (AYUSH) ministry of India has all these qualities to face the future challenges in the interventions to deal with endometriosis.
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Endometriosis – the new approach and homoeopathic therapeutics DOI: https://doi.org/10.18203/2320-1770.ijrcog20263480Keywords: Endometriosis, Mitochondria, Hormones, Homoeopathy, RCH, MCHAbstract An integral part of public health and especially the reproductive health since decades is the condition of endometriosis. The reproductive and child health (RCH) is a large chunk of the entire national health mission (NHM) where primarily the target is maternal and child health (MCH). As part of MCH and RCH, this article discusses the issue of endometriosis in the domain of reproductive life of a woman. It traverses through the fact that endometriosis in reproductive health is not only under the umbrella of hormonal domain but also it is a part of the cellular and metabolic functions in the body. The term cellular is aimed at the power house of the cell located in the cytoplasm, the mitochondria. The mitochondrial lens will help the medical fraternity to see the clinical condition of endometriosis in the perspective of new and emerging research. Simultaneously, it will help in comprehending the issues of pain, inflammation and cellular energy in endometriosis. With the new approach, missions, programs, strategies, objectives, activities and policies will have to be tuned with the issue of endometriosis. A holistic approach is the need of the hour amidst the current approaches that were primarily hormonal and surgical. Medical and clinicians need to adopt a therapeutic that is preventive, resilient, cost effective, clinical effective and has no side effects. Homoeopathy of ayurveda, yoga and naturopathy, unani, siddha, and homoeopathy (AYUSH) ministry of India has all these qualities to face the future challenges in the interventions to deal with endometriosis. Metrics References Penman I, Ralston SH, Strachan M, Hobson R. Davidson, Principles & Practice of Medicine, ELBS 16th Edition, Longman Group (FE) Limited. 24th Edition. Elsevier Limited Publishers; 2023. Benagiano G, Brosens I, Lippi D. The history of endometriosis. Gynecol Obstet Invest. 2014;78(1):1-9. DOI: https://doi.org/10.1159/000358919 Wang Y, Nicholes K, Shih IM. The Origin and Pathogenesis of Endometriosis. Annu Rev Pathol. 2020;15:71-95. DOI: https://doi.org/10.1146/annurev-pathmechdis-012419-032654 Shen D, Qi C, Hu P, Li J, Shen Y. Mitochondrial Involvement in the Pathogenesis of Endometriosis and its Potential as Therapeutic Targets. Reprod Sci. 2025;32(4):935-49. DOI: https://doi.org/10.1007/s43032-025-01827-5 Kobayashi H, Matsubara S, Yoshimoto C, Shigetomi H, Imanaka S. The role of mitochondrial dynamics in the pathophysiology of endometriosis. J Obstet Gynaecol Res. 2023;49(12):2783-91. DOI: https://doi.org/10.1111/jog.15791 Rong YS, Zhu J, Wang CC, Zhang J, Chen YC. Aberrant mitochondria in endometriosis: From pathogenic mechanisms to therapeutic opportunities. iScience. 2026;29(6):115916. DOI: https://doi.org/10.1016/j.isci.2026.115916 Atkins HM, Bharadwaj MS, O'Brien Cox A, Furdui CM, Appt SE, Caudell DL. Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model. Reprod Biol Endocrinol. 2019;17(1):70. DOI: https://doi.org/10.1186/s12958-019-0513-8 Marino Y, Inferrera F, Genovese T, Cuzzocrea S, Fusco R, Di Paola R. Mitochondrial dynamics: Molecular mechanism and implications in endometriosis. Biochimie. 2025;231:163-75. DOI: https://doi.org/10.1016/j.biochi.2025.01.012 Kay N, Huang C, Yu Y, The Involvement of Mitochondrial Dysfunction during the Development of Adenomyosis. Am J Pathol. 2025;195:861-74. DOI: https://doi.org/10.1016/j.ajpath.2025.01.014 Endonews. Alterations of mitochondrial dynamics in endometriosis, news & research portal of the endometriosis foundation of America since 2017. Available at: https://www.endonews.com. Accessed on 15 June 2026. Tripathy T, Nayak C, Das S, Singh DP, Tripathy B, Dwivedi R, et al. Endometriosis & Homoeopathy. Indian J Appl Res. 2024;14(07). Murphy R. Lotus Materia Medica. 3rd edition. B. Jain Publishers (P) Ltd; 2017. Murphy R. Homoeopathic Medical Repertory. 3rd edition. B. Jain Publishers (p) Ltd; 2017. Phatak SR. A Concise Repertory of Homoeopathic Medicines. Reprint edition. B. Jain Publishers (P) Ltd; 2002. Allen HC. Key notes and characteristics with comparisons of some of the leading remedies of the Homoeopathic Materia Medica with Bowel Nosodes. Reprint edition. B. Jain Publishers Pvt. Ltd; 1993. Boericke W. New Manual of Homoeopathic Materia Medica with Repertory. Reprint edition. B Jain Publishers Private Limited; 2008. Downloads Published How to Cite Issue Section License Copyright (c) 2026 Tridibesh Tripathy, Anjali Tripathy, Sanskriti Tripathy This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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