Peculiarities of the hormonal status on treatment of the patients with dysfunctional uterine bleeding (dub) during the premenopause with gestagens and combination of estrogen-gestagen preparations

166 patient (average age 44,820,40) with dysfunctional uterine bleeding (DUB) during premenopause were followed up. They were found to have hyperplasia of the endometrium of different forms. Hormonal therapy with different preparations (norcolut, orgametril, demulen, oxyprogesteron-capronat) was used. The patients with DUB during the premenopause may have different levels of gonadotropic and steroid hormones both on the background of DUB and during their treatment. These changes depend on a number of causes: age peculiarities, starting condition of hormonal homeostasis and mechanism of therapy action. We came to the conclusion that effectiveness of the treatment had not depended essentially on the patients' age, dynamics of peptid and steroid hormones level and type of the hormonal therapy to be used.