The Continuous Treatment of Anterior Segment Open Globe Injury: Eye Injury Vitrectomy Study

Background: To evaluate whether better prognosis can be obtained from the continuous surgical treatment (CST) before fibrosis /scar formation in open anterior segment (AS) injury. Methods: : Prospective cohort study.19 eyes of 19 patients were selected from the database of Eye Injury Vitrectomy Study, which is a multi-center prospective cohort study and began in 1990s, from January 1, 2020 to July 31, 2021. Of these, 9 patients who received CST were assigned to group 1, and 10 patients without continuous treatment after initial wound repairment were included in group 2. Comparison between two groups was conducted in final best corrected visual acuity (BCVA), presumably significant complications with X² test. Corneal leucoma area ratio, astigmatism and score of AS abnormalities were analyzed by Students’ t-test. Results: : Gross appearance displays remarkable differences between two groups with observation on AS. The individually paradigm, such as corneal-scleral wound and intraocular abnormalities, can be noted over various post-traumatic time intervals. The final BCVA is better in group 1(P=0.011). The complications directly caused by AS injury, adhesive corneal leucoma, uneven anterior chamber, block of light pass through pupil and fibrosis/scar are more frequent in group 2 (P=0.011, 0.022, 0.037 and 0.040, respectively). Secondary glaucoma (three cases) and severe AS structure destruction (two cases) occurred only in group 2 (P=0.037 and 0.474, respectively). Conclusions: : Relying on comprehensive evaluations, advantages of CST of initiating before fibrosis/scar formation in open AS injury show dominance over following nature course of wound healing after wound repairment.